Vortioxetine

(Trintellix)

Vortioxetine

Drug updated on 11/10/2023

Dosage FormTablet (oral; 5 mg, 10 mg, 15 mg, 20 mg)
Drug ClassAntidepressants
Ongoing and Completed StudiesClinicalTrials.gov

Indication

  • For the treatment of major depressive disorder (MDD) in adults.

Product Monograph / Prescribing Information

Document TitleYearSource
Trintellix (vortioxetine) Prescribing Information.2021Takeda Pharmaceuticals America, Deerfield, IL

Systematic Reviews / Meta-Analyses

Document TitleYearSource
Effectiveness and safety of vortioxetine for the treatment of major depressive disorder in the real world: a systematic review and meta-analysis.2023International Journal of Neuropyschopharmacology
Εfficacy and safety of vortioxetine (Lu AA21004) in the treatment of adult patients with major depressive disorder: A systematic review and a meta‑analysis of randomized controlled trials.2023Experimental and Therapeutic Medicine
Antidepressants for the treatment of adults with major depressive disorder in the maintenance phase: a systematic review and network meta-analysis.2023NPG Open Access
A comprehensive review and meta-analysis of neurological side effects related to second-generation antidepressants in individuals with major depressive disorder.2023Behavioural Brain Research
Systematic review and meta-analysis of vortioxetine for the treatment of major depressive disorder in adults.2022Frontiers in Psychiatry
Effect of vortioxetine on cognitive impairment in patients with major depressive disorder: a systematic review and meta-analysis of randomized controlled trials.2022International Journal of Neuropsychopahrmacology
The Incidence and Costs of Adverse Events Associated with Antidepressants: Results from a Systematic Review, Network Meta-Analysis and Multi-Country Economic Model.2022Neuropsychiatric Disease and Treatment
Antidepressants for depressed patients with type 2 diabetes mellitus: A systematic review and network meta-analysis of short-term randomized controlled trials.2022Neuroscience and Biobehavior Reviews
Efficacy and safety of vortioxetine in treatment of patients with major depressive disorder and common co-morbid physical illness.2022Journal of Affective Disorders
Comparative efficacy of pharmacological treatments on measures of self-rated functional outcomes using the Sheehan Disability Scale in patients with major depressive disorder: a systematic review and network meta-analysis.2021CNS Spectrums
Gastrointestinal side effects associated with antidepressant treatments in patients with major depressive disorder: a systematic review and meta-analysis.2021Progress in Neuro-Psychopharmacology and Biological Psychiatry
Vortioxetine Versus Placebo for Major Depressive Disorder: A Comprehensive Analysis of the Clinical Trial Dataset.2021Journal of Clinical Psychiatry
Cognitive effects of vortioxetine in older adults: a systematic review.2021Therapeutic Advances in Psychopharmacology
Clinical review report: vorioxetine hydrobromide (Trintellix).2020CADTH
Systematic review of gender bias in vortioxetine clinical trials.2020Progress in Neuro-Psychopharmacology and Biological Psychiatry
Procognitive Effects of Antidepressants and Other Therapeutic Agents in Major Depressive Disorder: A Systematic Review.2020Journal of Clinical Psychiatry
Efficacy and tolerability of pharmacological and non-pharmacological interventions in older patients with major depressive disorder: a systematic review, pairwise and network meta-analysis.2019European Neuropsychopharmacology
The efficacy and safety of 10 mg/day vortioxetine compared to placebo for adult major depressive disorder: a meta-analysis.2019African Health Sciences
Efficacy and safety of levomilnacipran, vilazodone and vortioxetine compared with other second-generation antidepressants for major depressive disorder in adults: a systematic review and network meta-analysis.2018Journal of Affective Disorders
Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis.2018The Lancet
A Network Meta-Analysis Comparing Effects of Various Antidepressant Classes on the Digit Symbol Substitution Test (DSST) as a Measure of Cognitive Dysfunction in Patients with Major Depressive Disorder.2018International Journal of Neuropsychopharmacology
Efficacy of vortioxetine on the physical symptoms of major depressive disorder.2018Journal of Psychopharmacology
Relative short-term efficacy and acceptability of agomelatine versus vortioxetine in adult patients suffering from major depressive disorder.2018Human Psychopharmacology

Clinical Practice Guidelines