Summary

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• This summary is based on the review of 13 systematic review(s)/meta-analysis(es). ^[1-13]
• Vortioxetine significantly reduced depressive symptoms and improved cognitive function in adults with MDD (major depressive disorder) at doses of 5-20 mg, with notable improvements in MADRS (Montgomery-Asberg Depression Rating Scale), SDS (Sheehan Disability Scale), CGI-I (Clinical Global Impression Scale-Improvement), and DSST (Digit Symbol Substitution Test) scores, especially at 10 and 20 mg.
• Compared to placebo, vortioxetine demonstrated higher response and remission rates and enhanced cognitive function, with no significant differences in efficacy compared to SNRIs and SSRIs.
• In patients with comorbid cardiovascular disease or diabetes, vortioxetine use resulted in significant reductions in MADRS scores, supporting its efficacy in MDD populations with specific comorbidities.
• Limited evidence suggests potential cognitive benefits for older adults with depressive symptoms, while efficacy in children and adolescents remains uncertain due to low-certainty evidence.
• The most common adverse events associated with vortioxetine were nausea, hyperhidrosis, insomnia, and vomiting, with adverse events increasing at higher doses. Nausea was the most frequently reported in real-world data, with an estimated rate of 8.9%.
• Compared to SNRIs, vortioxetine demonstrated better tolerability without significant differences in response or remission rates. No significant differences in response or remission rates were observed compared to SSRIs, though vortioxetine had a higher incidence of nausea/vomiting than placebo.
• In specific populations, none of the six hospitalized patients developed serious safety issues, with only one case of mild-to-moderate nausea reported. For patients with comorbid cardiovascular disease or diabetes, the safety profile of vortioxetine aligned with expected treatment outcomes, without unexpected adverse events.