Summary

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• Tazemetostat (Tazverik) is indicated for the treatment of adults and pediatric patients aged 16 years and older with metastatic or locally advanced epithelioid sarcoma not eligible for complete resection. It is also used for treating adult patients with relapsed or refractory follicular lymphoma whose tumors are positive for an EZH2 mutation as detected by an FDA-approved test, especially for those who have received at least two prior systemic therapies.
• Three systematic reviews/meta-analyses provided valuable comparative data on Tazemetostat, setting its therapeutic profile within the context of existing treatment options.
• Compared to PI3K inhibitors such as idelalisib, duvelisib, copanlisib, umbralisib, Tazemetostat exhibits a significantly lower relative risk for all grouped safety outcomes including any grade ≥3 treatment-emergent adverse events (TEAEs), serious TEAEs, and TEAEs leading to dose reduction or interruption, suggesting a better safety profile in treating R/R FL.
• In terms of efficacy, Mosunetuzumab generally was favored over Tazemetostat among EZH2 wild-type patients, indicating superior efficacy but it was noted that genetic subtypes play a significant role in moderating the effectiveness of these drugs.
• While CART therapies showed favorable outcomes regarding progression-free survival (PFS) compared to Tazemetostat, there remain uncertainties due to differences in study designs, making direct comparisons challenging without uniformity across studies.
• The focus on pretreated R/R FL patients suggests Tazemetostat's role when several prior lines of therapy have failed, presenting it as a compelling option given its lower risk of severe TEAEs, while considering population types like those with or without EZH2 mutations, showing tailored efficacy based on genetic markers.