Drug updated on 5/17/2024

Dosage FormTablet (oral; 200 mcg, 400 mcg, 600 mcg, 800 mcg, 1000 mcg, 1200 mcg, 1400 mcg, 1600 mcg); Injection (Intravenous; 1800 mcg)
Drug ClassProstacyclin receptor agonists
Ongoing and
Completed Studies


  • Indicated for the treatment of pulmonary arterial hypertension (PAH, WHO Group I) to delay disease progression and reduce the risk of hospitalization for PAH.

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  • Selexipag (Uptravi) is used for the treatment of pulmonary arterial hypertension (PAH), primarily to delay disease progression and reduce the risk of hospitalization.
  • The safety profile of selexipag indicates that it has common tolerable side effects such as headache, nausea, and diarrhea in more than 70% of patients. It also demonstrates a similar safety profile to other oral therapies targeting the prostacyclin pathway, such as oral treprostinil.
  • In terms of effectiveness, selexipag improves key indicators including the 6-minute walk distance (6-MWD), mean pulmonary arterial pressure (mPAP), and WHO functional class across various populations. This includes pediatric patients and those with Connective Tissue Disease-associated PAH (CTD-PAH).
  • Different dosage levels—low, medium, or high—all show efficacy in improving health outcomes related to PAH. However, there is an increased likelihood of treatment discontinuation due to adverse events when compared to placebo.
  • For specific population types, pediatric patients find this drug promising, showing potential for add-on therapy; while CTD-PAH patients have shown favorable effects on clinical outcomes from treatments that include selexipag.
  • Eight studies providing comprehensive information about Uptravi's use in treating PAH were reviewed.