Sarecycline

(Seysara®)

Sarecycline

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Drug updated on 5/17/2024

Dosage FormTablet (oral: 60 mg, 100 mg, 150 mg)
Drug ClassTetracycline class antibacterials
Ongoing and
Completed Studies
ClinicalTrials.gov

Indication

  • Indicated for the treatment of inflammatory lesions of non-nodular moderate to severe acne vulgaris in patients ≥ 9 years of age.

Summary
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  • Sarecycline (Seysara) is approved for the management of inflammatory lesions of non-nodular moderate to severe acne vulgaris in individuals aged 9 years and older.
  • One systematic review/meta-analysis compared the safety and effectiveness of sarecycline with other antibiotics in the tetracycline class, such as doxycycline, minocycline, and tetracycline.
  • The study involved a large sample of 226,019 pediatric and adult patients suffering from acne. This sizeable sample size suggests the results can be applied across typical demographic groups encountered in various settings.
  • Sarecycline showed effectiveness in treating both facial and truncal acne, indicating a potentially broader scope of action compared with doxycycline, minocycline, or tetracycline.
  • Concerns regarding antibiotic resistance and gut dysbiosis were highlighted. Although the study did not provide a detailed comparison of these issues among the different antibiotics, sarecycline's status as a novel narrow-spectrum tetracycline suggests it might have a reduced impact on gut flora and may contribute less to antibiotic resistance.
  • The inclusion of both pediatric and adult populations without specifying subgroup considerations underscores the drug's wide applicability for various age groups suffering from Acne Vulgaris.

Product Monograph / Prescribing Information

Document TitleYearSource
Seysara (sarecycline) Prescribing Information.2021Almirall LLC, Malvern, PA

Systematic Reviews / Meta-Analyses

Document TitleYearSource
Oral tetracyclines and acne: a systematic review for dermatologists.2020Journal of Drugs in Dermatology

Clinical Practice Guidelines

Document TitleYearSource
Guidelines of care for the management of acne vulgaris.2024Journal of the American Academy of Dermatology