Summary

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• Sarecycline (Seysara) is approved for the management of inflammatory lesions of non-nodular moderate to severe acne vulgaris in individuals aged 9 years and older.
• One systematic review/meta-analysis compared the safety and effectiveness of sarecycline with other antibiotics in the tetracycline class, such as doxycycline, minocycline, and tetracycline.
• The study involved a large sample of 226,019 pediatric and adult patients suffering from acne. This sizeable sample size suggests the results can be applied across typical demographic groups encountered in various settings.
• Sarecycline showed effectiveness in treating both facial and truncal acne, indicating a potentially broader scope of action compared with doxycycline, minocycline, or tetracycline.
• Concerns regarding antibiotic resistance and gut dysbiosis were highlighted. Although the study did not provide a detailed comparison of these issues among the different antibiotics, sarecycline's status as a novel narrow-spectrum tetracycline suggests it might have a reduced impact on gut flora and may contribute less to antibiotic resistance.
• The inclusion of both pediatric and adult populations without specifying subgroup considerations underscores the drug's wide applicability for various age groups suffering from Acne Vulgaris.