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Praxbind

Chemical Nameidarucizumab
Dosage FormInjection (intravenous; 2.5 g/50 mL)
Drug ClassHumanized monoclonal antibody fragment (Fab)
SystemVarious
CompanyBoehringer Ingelheim
Approval Year2015

Indication

  • Indicated in patients treated with Pradaxa® when reversal of the anticoagulant effects of dabigatran is needed for emergency surgery/urgent procedures or in life-threatening or uncontrolled bleeding.
Document TitleYearSource
Praxbind (idarucizumab) Prescribing Information.2021Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT
Document TitleYearSource
Intravenous thrombolysis after dabigatran reversal by idarucizumab: a systematic review of the literature.2021Frontiers in Neurology
Use of direct-acting oral anticoagulants in solid organ transplantation: a systematic review.2021Pharmacotherapy
Incomplete responses to the recommended dose of idarucizumab: a systematic review and pharmacokinetic analysis.2020Clinical Toxicology
Dabigatran reversal by idarucizumab in the setting of intracranial hemorrhage: a systematic review of the literature.2019Clinical Neurology and Neurosurgery
The reversal of bleeding caused by new oral anticoagulants (NOACs): a systematic review and meta-analysis.2018Clinical and Applied Thrombosis/Hemostasis
Idarucizumab for reversing dabigatran-induced anticoagulation: a systematic review.2018American Journal of Therapeutics
Document TitleYearSource
American college of gastroenterology-canadian association of gastroenterology clinical practice guideline: management of anticoagulants and antiplatelets during acute gastrointestinal bleeding and the periendoscopic period.2022The American Journal of Gastroenterology
European Stroke Organisation guideline on reversal of oral anticoagulants in acute intracerebral haemorrhage.2019European Stroke Journal
2019 AHA/ACC/HRS focused update of the 2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: a report of the american college of cardiology/american heart association task force on clinical practice guidelines and the heart rhythm society in collaboration with the society of thoracic surgeons.2019Circulation
American Society of Hematology 2018 guidelines for management of venous thromboembolism: optimal management of anticoagulation therapy.2018Blood Advances
Management of bleeding and emergency invasive procedures in patients on dabigatran: Updated guidelines from the French Working Group on Perioperative Haemostasis (GIHP) - September 2016.2018Anaesthesia, Critical Care & Pain Medicine
Drug updated on 6/5/2023

More on this drug: Clinical Trials