Drug updated on 5/3/2024
Dosage Form | Injection (intravenous; 1 mg/mL, 2 mg/2 mL [1 mg/mL] in single-dose vials, 30 mg/30 mL [1 mg/mL] in single-patient-use vial) |
Drug Class | Opioid agonists |
Ongoing and Completed Studies | ClinicalTrials.gov |
Indication
- Indicated in adults for the management of acute pain severe enough to require an intravenous opioid analgesic and for whom alternative treatments are inadequate.
Summary
- Oliceridine (Olinvyk) is indicated for the management of acute pain severe enough to require an intravenous opioid analgesic and for whom alternative treatments are inadequate.
- A systematic review and meta-analysis was conducted on one document that evaluated the efficacy and safety of oliceridine in patients with postoperative pain.
- The study found that a higher proportion of patients responded significantly to oliceridine compared to placebo, showing its effectiveness as a postoperative analgesic.
- When comparing oliceridine's effects with morphine, it was observed that both had similar levels of treatment response and analgesia effects; however, fewer respiratory safety events were reported with oliceridine use than morphine use.
- Despite its benefits, adverse events such as nausea and vomiting were more frequently associated with Olinerivide (Olinvyk) than placebo.
- Overall, despite some adverse events like nausea or vomiting being more common compared to placebos, the safety profile of Olinerivide (Olinvyk) was deemed superior to Morphine making it a viable option for managing severe acute pain where other treatments have proven inadequate.
Product Monograph / Prescribing Information
Document Title | Year | Source |
---|---|---|
Olinvyk (oliceridine) Prescribing Information. | 2021 | Trevena, Inc., Chesterbrook, PA |
Systematic Reviews / Meta-Analyses
Document Title | Year | Source |
---|---|---|
Efficacy and safety of oliceridine treatment in patients with postoperative pain: a systematic review and meta-analysis of randomized controlled trials. | 2023 | Expert Review of Clinical Pharmacology |
Oliceridine for the management of moderate to severe acute postoperative pain: a narrative review. | 2023 | Drug Design, Development and Therapy |