Drug updated on 11/5/2024
| Dosage Form | Injection (intravenous; 1 mg/mL, 2 mg/2 mL [1 mg/mL] in single-dose vials, 30 mg/30 mL [1 mg/mL] in single-patient-use vial) |
| Drug Class | Opioid agonists |
| Ongoing and Completed Studies | ClinicalTrials.gov |
Indication
- Indicated in adults for the management of acute pain severe enough to require an intravenous opioid analgesic and for whom alternative treatments are inadequate.
Latest News
Summary
- This summary is based on the review of three systematic review(s)/meta-analysis(es). [1-3]
- Oliceridine demonstrated comparable analgesic effectiveness to morphine, with a significantly higher proportion of treatment responders than placebo across multiple studies. The analgesic effects of oliceridine were also similar to those of morphine.
- The incidence of respiratory safety events was significantly lower with oliceridine compared to morphine, suggesting a safer profile in terms of respiratory complications.
- Oliceridine was associated with a significantly lower incidence of nausea and vomiting requiring antiemetics in orthopedic surgery compared to hydromorphone, although this trend was not statistically significant in plastic surgery.
- There is no population types or subgroups information available in the reviewed studies.
Product Monograph / Prescribing Information
| Document Title | Year | Source |
|---|---|---|
| Olinvyk (oliceridine) Prescribing Information. | 2023 | Trevena, Inc., Chesterbrook, PA |
Systematic Reviews / Meta-Analyses
| Document Title | Year | Source |
|---|---|---|
| Gastrointestinal adverse effects associated with the use of intravenous oliceridine compared with intravenous hydromorphone or fentanyl in acute pain management utilizing adjusted indirect treatment comparison methods | 2024 | Journal of Comparative Effectiveness Research |
| Efficacy and safety of oliceridine treatment in patients with postoperative pain: a systematic review and meta-analysis of randomized controlled trials | 2023 | Expert Review of Clinical Pharmacology |
| Oliceridine for the Management of Moderate to Severe Acute Postoperative Pain: A Narrative Review | 2023 | Drug Design, Development and Therapy |