Drug updated on 4/16/2024
| Dosage Form | Tablet (oral; 2 mg) |
| Drug Class | Antihelmintics |
| Ongoing and Completed Studies | ClinicalTrials.gov |
Indication
- Moxidectin is indicated for the treatment of onchocerciasis due to Onchocerca volvulus in patients aged 12 years and older.
Summary
- Moxidectin (moxidectin) is indicated for the treatment of onchocerciasis due to Onchocerca volvulus in patients aged 12 years and older.
- Two systematic reviews/meta-analyses were reviewed, providing insights into the efficacy and safety of moxidectin in treating parasitic infections.
- The first review reveals that moxidectin has been under clinical trials for five years to evaluate its effectiveness against other helminthic infections such as Strongyloides stercoralis and Trichuris trichiura, which are prevalent in resource-limited countries.
- This study suggests that moxidectin could complement existing treatments for soil-transmitted helminthiasis when administered alone or combined with other antiparasitic medications.
- The second review discusses a comprehensive review of literature up until September 2020 assessing the use of moxidectin against parasites across various mammalian species; it was found effective but had some mild adverse effects reported in a small percentage of individuals treated with this drug.
- Despite these minor side effects, no additional therapies were required as symptoms typically resolved themselves; however, further studies are recommended to assess its efficacy across more species especially wildlife populations where data is currently limited.
Product Monograph / Prescribing Information
| Document Title | Year | Source |
|---|---|---|
| Moxidectin (moxidectin) Prescribing Information. | 2021 | Medicines Development for Global Health, Melbourne, Victoria, Australia |
Systematic Reviews / Meta-Analyses
| Document Title | Year | Source |
|---|---|---|
| Can moxidectin be an anthelmintic alternative for trichuris trichiura and strongyloides stercoralis: a systematic review. | 2022 | Cureus |
| A systematic review of moxidectin as a treatment for parasitic infections in mammalian species. | 2021 | Parasitology Research |