Drug updated on 5/17/2024
Dosage Form | Injection (intravenous: 20 mg/5 mL [4 mg/mL]) |
Drug Class | CC chemokine receptor type 4 (CCR4)- directed monoclonal antibodies |
Ongoing and Completed Studies | ClinicalTrials.gov |
Indication
- Indicated for the treatment of adult patients with relapsed or refractory mycosis fungoides or Sézary syndrome after at least one prior systemic therapy.
Latest News
![loading GIF](/img/news-loading.gif)
Summary
- Mogamulizumab-kpkc (Poteligeo) is approved for the use in adult patients with relapsed or refractory mycosis fungoides or Sézary syndrome following at least one prior systemic therapy. It is a unique IgG1κ monoclonal antibody that targets the chemokine receptor type 4 (CCR4). A significant side effect is the mogamulizumab-associated rash, which affects up to a quarter of patients and is the primary reason for discontinuation.
- Three systematic reviews/meta-analyses focus on Poteligeo's effectiveness in treating these conditions and its implications in the management of adult T-cell leukemia-lymphoma (ATL).
- When compared to other therapies such as allo-HSCT and various chemotherapy regimens, mogamulizumab presents a unique side effect profile primarily involving cutaneous reactions, whereas systemic treatments often come with a wider range and potentially more severe adverse effects.
- In cases of relapsed/refractory ATL, mogamulizumab has shown potential for longer survival in comparison to traditional chemotherapy and allo-HSCT approaches. This indicates that it may provide a significant therapeutic benefit in situations where other treatment options have failed.
- Regarding mycosis fungoides, no treatment, including mogamulizumab, has conclusively proven to be superior over conventional therapies concerning disease-free intervals, relapse rates, or overall survival. Clinically, there is a preference for topical/skin-directed therapies due to their superior safety profile and fewer systemic adverse effects, compared to more aggressive treatments such as chemotherapy/mogamulizumab.
- The management of mogamulizumab-induced side effects requires immediate clinical response; further research should aim at understanding the prognostic significance and identifying genomic markers for these events to enhance patient care. More comprehensive studies are needed to explore the drug's efficacy, side effect profile, and impact on the quality of life across different stages of the diseases treated by mogamulizumab.
Product Monograph / Prescribing Information
Document Title | Year | Source |
---|---|---|
Poteligeo (mogamulizumab-kpkc) Prescribing Information. | 2023 | Kyowa Kirin, Inc., Bedminster, NJ |
Systematic Reviews / Meta-Analyses
Document Title | Year | Source |
---|---|---|
Clinicopathological definition, management and prognostic value of mogamulizumab-associated rash and other cutaneous events: a systematic review. | 2024 | Journal of the European Academy of Dermatology and Venereology |
Systematic review of survival outcomes for relapsed or refractory adult T-cell leukemia-lymphoma. | 2022 | European Journal of Haematology |
Interventions for mycosis fungoides. | 2020 | The Cochrane Database of Systematic Reviews |
Clinical Practice Guidelines
Document Title | Year | Source |
---|---|---|
Mogamulizumab for previously treated mycosis fungoides and sézary syndrome: an evidence review group perspective of a NICE single technology appraisal. | 2022 | PharmacoEconomics |
Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immunotherapy for the treatment of lymphoma. | 2020 | Journal for ImmunoTherapy of Cancer |