Loncastuximab tesirine-lpyl

(Zynlonta®)

Loncastuximab tesirine-lpyl

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Drug updated on 5/17/2024

Dosage FormInjection (intravenous; 10 mg)
Drug ClassCD19-directed antibody and alkylating agent
Ongoing and
Completed Studies
ClinicalTrials.gov

Indication

  • Indicated for the treatment of adult patients with relapsed or refractory large B-cell lymphoma after two or more lines of systemic therapy, including diffuse large B-cell lymphoma (DLBCL) not otherwise specified, DLBCL arising from low grade lymphoma, and high-grade B-cell lymphoma.

Summary
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  • Loncastuximab tesirine-lpyl (Zynlonta) is indicated for the treatment of adult patients with relapsed or refractory large B-cell lymphoma after two or more lines of systemic therapy. This includes diffuse large B-cell lymphoma not otherwise specified, DLBCL arising from low-grade lymphoma, and high-grade B-cell lymphoma.
  • A study evaluated the efficacy of Zynlonta among other treatments for relapsed or refractory diffuse large B-cell lymphoma.
  • The study compared Zynlonta to CAR T-cell therapy, finding no significant difference in efficacy after adjusting for the median number of previous lines of treatment. This suggests that Zynlonta can potentially offer comparable efficacy to CAR T-cell therapy in treating R/R DLBCL.
  • For patients ineligible for Autologous Stem Cell Transplantation (ASCT), tafasitamab showed a better 1-year PFS rate than CAR T-cell therapy. However, this does not directly compare its effectiveness with Zynlonta.
  • The analysis also divided cohorts into those eligible for Autologous Stem Cell Transplantation (ASCT) and those who are not. It suggested that Zynlonta could be particularly beneficial as an alternative treatment route with similar efficiency as leading therapies like CAR-T cell especially for patients ineligible for ASCT.
  • Overall, based on this solitary analysis, newer agents such as loncastuximab tesirine-lpyl appear promising in offering substantive benefits, specifically within certain subgroups where traditional chemotherapies may fall short due to their eligibility criteria, such as the requirement for ASCT candidacy.

Product Monograph / Prescribing Information

Document TitleYearSource
Zynlonta (loncastuximab tesirine-lpyl) Prescribing Information.2021ADC Therapeutics SA., Route de la Corniche, Epalinges, Switzerland

Systematic Reviews / Meta-Analyses