Levetiracetam

(Keppra)

Levetiracetam

Drug updated on 10/23/2023

Dosage FormTablet (oral: 250 mg, 500 mg, 750 mg, 1000 mg) Solution (oral: 100 mg/ml)
Drug ClassAnticonvulsants
Ongoing and Completed StudiesClinicalTrials.gov

Indication

  • For the treatment of partial-onset seizures in patients 1 month of age and older.
  • For the treatment of adjunctive therapy for the treatment of myoclonic seizures in patients 12 years of age and older with juvenile myoclonic epilepsy
  • For the treatment of adjunctive therapy for the treatment of primary generalized tonic-clonic seizures in patients 6 years of age and older with idiopathic generalized epilepsy.

Product Monograph / Prescribing Information

Document TitleYearSource
Keppra (levetiracetam) Prescribing Information.2023UCB, Inc. Smyrna, GA

Systematic Reviews / Meta-Analyses

Document TitleYearSource
The safety of rapid infusion levetiracetam: a systematic review.2022Pharmacotherapy
Levetiracetam for seizure prophylaxis in neurocritical care: a systematic review and meta-analysis.2021Neurocritical Care
Population pharmacokinetics of levetiracetam: a systematic review.2021Clinical Pharmacokinetics
Levetiracetam as the first-line treatment for neonatal seizures: a systematic review and meta-analysis.2021Developmental Medicine & Child Neurology
Efficacy and safety of levetiracetam vs. phenobarbital for neonatal seizures: a systematic review and meta-analysis.2021Frontiers in Neurology
Efficacy and safety of levetiracetam vs. phenytoin as second line antiseizure medication for pediatric convulsive status epilepticus: a systematic review and meta-analysis of randomized controlled trials.2021Journal of Tropical Pediatrics
Efficacy of levetiracetam for migraine prophylaxis: a systematic review and meta-analysis.2021Journal of Formosan Medical Association
Efficacy, safety, and economics of intravenous levetiracetam for status epilepticus: a systematic review and meta-analysis.2020Frontiers in Pharmacology
Levetiracetam for convulsive status epilepticus in childhood: systematic review and meta-analysis.2020Archives of Disease in Childhood
Levetiracetam versus phenytoin for the treatment of established status epilepticus: a systematic review and meta-analysis of randomized controlled trials.2020Seizure European Journal of Epilepsy
Levetiracetam and cutaneous adverse reactions: a systematic review of descriptive studies.2020Seizure European Journal of Epilepsy
Levetiracetam vs. phenytoin as 2nd-line treatment for status epilepticus: a systematic review and meta-analysis.2020Epilepsy & Behaviour
Levetiracetam as preventive treatment in adults with migraine: an up-to-date systematic review and quantitative meta-analysis.2019European Journal of Clinical Pharmacology

Clinical Practice Guidelines