Drug updated on 9/4/2024
Dosage Form | solution (topical ophthalmic; 0.24 mg/mL [0.024%]) |
Drug Class | Prostaglandin analogs |
Ongoing and Completed Studies | ClinicalTrials.gov |
Indication
- Indicated for the reduction of intraocular pressure in patients with open-angle glaucoma or ocular hypertension.
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Summary
- Vyzulta (latanoprostene bunod ophthalmic solution) is indicated for the reduction of intraocular pressure in patients with open-angle glaucoma or ocular hypertension.
- This summary is based on the review of one systematic review(s)/meta-analysis(es). [1]
- LBN vs. Unoprostone: Latanoprostene bunod (LBN) demonstrated a significant reduction in intraocular pressure (IOP) with a mean difference of -3.45 mmHg (95% CI: -4.77 to -2.12) compared to unoprostone.
- LBN vs. Other Prostaglandin Analogues (PGAs): LBN showed a non-significant reduction in IOP compared to latanoprost (-0.70 mmHg; 95% CI: -1.83 to 0.43), tafluprost (-0.41 mmHg; 95% CI: -1.87 to 1.07), bimatoprost 0.01% (-0.02 mmHg; 95% CI: -1.59 to 1.55), and was slightly less effective than bimatoprost 0.03% (-0.17 mmHg; 95% CI: -1.42 to 1.07).
- LBN vs. Beta-blockers: LBN was significantly more effective in lowering IOP compared to several beta-blockers, including apraclonidine, betaxolol, brimonidine, brinzolamide, carteolol, dorzolamide, and timolol.
- There is no safety information available in the reviewed studies.
- There is no population types or subgroups information available in the reviewed studies.
Product Monograph / Prescribing Information
Document Title | Year | Source |
---|---|---|
Vyzulta (latanoprostene bunod ophthalmic solution) Prescribing Information. | 2019 | Bausch Health US, LLC., Bridgewater, NJ |
Systematic Reviews / Meta-Analyses
Document Title | Year | Source |
---|---|---|
Short-term efficacy of latanoprostene bunod for the treatment of open-angle glaucoma and ocular hypertension: a systematic literature review and a network meta-analysis. | 2022 | British Journal of Ophthalmology |
Clinical Practice Guidelines
Document Title | Year | Source |
---|---|---|
Primary open-angle glaucoma preferred practice pattern. | 2021 | Ophthalmology |