Summary

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• Pizensy (lactitol) is indicated for the treatment of chronic idiopathic constipation (CIC) in adults.
• This summary is based on the review of one systematic review(s)/meta-analysis(es). ^[1]
• Lactitol was more effective than placebo in managing constipation in elderly patients over the short term (up to 3 months), similar to other laxatives such as psyllium, calcium polycarbophil, lactulose syrup, and magnesium hydroxide.
• The review did not provide specific comparative effectiveness data between lactitol and other laxatives, but polyethylene glycol was highlighted as effective for long-term use (around 6 months), while lactitol’s effectiveness was only noted for short-term use.
• The studies focused on elderly patients over 65 years old, with no significant differences in effectiveness reported among subgroups within this population.
• Lactitol, along with other laxatives, was generally safe for short-term use (up to 3 months) in elderly patients, with similar frequency and severity of adverse effects across different treatment arms.
• There were no specific adverse effects or safety concerns highlighted for lactitol compared to other laxatives, and no particular safety concerns were noted for subgroups within the elderly population.