Summary

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• Fremanezumab-vfrm (Ajovy) is a monoclonal antibody targeting the calcitonin gene-related peptide pathway, approved for the preventive treatment of migraine in adults. It consistently shows a significant reduction in monthly migraine days and high rates of achieving at least a 50% reduction.
• The analysis was based on 28 studies that focused on aspects such as Ajovy's efficacy, safety, comparisons with other drugs, population, and subgroup considerations related to migraine prevention.
• Ajovy appears equally effective in episodic and chronic migraine subgroups. Certain dosing regimens offer optimal balances of efficacy and safety. It also proves effective for patients with medication-overuse headache (MOH) or those who had inadequate responses to other preventative measures like topiramate or BOTOX.
• In terms of safety profile, most adverse events associated with Ajovy are of mild to moderate severity, similar to placebo effects observed during clinical trials; injection site reactions being the most common adverse event reported.
• Long-term data suggests a good tolerability profile without any new identified safety signals over extended periods, making it safe for long-term use among adult patients suffering from migraines.
• When compared against other CGRP monoclonal antibodies like erenumab, galcanezumab, and eptinezumab; fremanezumab exhibits comparable efficacy and safety profiles, suggesting no significant difference between these treatments regarding reducing migraines or their respective side effects.
• Compared against oral preventatives such as topiramate and propranolol; fremanezumab has shown advantages by having higher likelihood-to-help-versus-harm values indicating its superior benefit-risk ratio, which makes it a more favorable option than traditional oral medications used for preventing migraines.
• Ajovy's effectiveness does not significantly vary between chronic versus episodic sufferers, making it a versatile preventative option across different types of migraines, irrespective of the gender bias prevalent within clinical trial recruitment and analysis.