Fidaxomicin

(Dificid)

Fidaxomicin

Drug updated on 11/9/2023

Dosage FormTablet (oral; 200 mg); Suspension (oral; 40 mg/mL)
Drug ClassMacrolide antibacterials
Ongoing and Completed StudiesClinicalTrials.gov

Indication

  • Indicated in adult and pediatric patients 6 months of age and older for the treatment of C. difficile-associated diarrhea.

Product Monograph / Prescribing Information

Document TitleYearSource
Dificid (fidaxomicin) Prescribing Information.2022Merck & Co., Inc., Rahway, NJ

Systematic Reviews / Meta-Analyses

Document TitleYearSource
Clostridioides difficile Infection in Inflammatory Bowel Disease Patients: A Systematic Review of Risk Factors and Approach in Management.2023Cureus
The effect of antibiotic therapy for Clostridioides difficile infection on mortality and other patient-relevant outcomes: a systematic review and meta-analysis.2023Clinical Microbiology and Infection
Oral fidaxomicin versus vancomycin for the treatment of Clostridioides difficile infection: a systematic review and meta-analysis of randomized controlled trials.2022Journal of Infection and Chemotherapy
Real-world comparison of fidaxomicin versus vancomycin or metronidazole in the treatment of Clostridium difficile infection: a systematic review and meta-analysis.2022European Journal of Clinical Pharmacology
Path of least recurrence: A systematic review and meta-analysis of fidaxomicin versus vancomycin for Clostridioides difficile infection.2022Pharmacotherpay
Health economic evaluations comparing faecal microbiota transplantation with antibiotics for treatment of recurrent Clostridioides difficile infection: a systematic review.2021Health Economics Review
Fidaxomicin compared with vancomycin and metronidazole for the treatment of Clostridioides (Clostridium) difficile infection: a network meta-analysis.2020Journal of Infection and Chemotherapy
Prevention of recurrent Clostridioides difficile infection: a systematic review of randomized controlled trials.2020Anaerobe
Antimicrobial resistance in Clostridioides (Clostridium) difficile derived from humans: a systematic review and meta-analysis.2020Antimicrobial Resistance and Infection Control
A network meta-analysis of randomized controlled trials exploring the role of fecal microbiota transplantation in recurrent Clostridium difficile infection.2019United European Gastroenterology
Cost-effectiveness of competing treatment strategies for clostridium difficile infection: a systematic review.2018Information Infection Control & Hospital Epidemiology
Fidaxomicin vs vancomycin for the treatment of a first episode of clostridium difficile infection: a meta-analysis and systematic review.2018Cureus
Comparative efficacy of treatments for Clostridium difficile infection: a systematic review and network meta-analysis.2018The Lancet Infectious Diseases
Cost-effectiveness of three different strategies for the treatment of first recurrent Clostridium difficile infection diagnosed in a community setting.2018Infection control and Hospital Epidemiology

Clinical Practice Guidelines

Document TitleYearSource
Clostridioides difficile infection: antimicrobial prescribing. 2021NICE
European Society of Clinical Microbiology and Infectious Diseases: 2021 update on the treatment guidance document for Clostridioides difficile infection in adults.2021Clinical Microbiology and Infection
Clinical practice guideline by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA): 2021 focused update guidelines on management of Clostridioides difficile infection in adults.2021Clinical Infectious Diseases
Guidelines for Clostridium difficile infection in adults.2020PrzeglÄ…d Gastroenterologiczny
Recommendations for the diagnosis and treatment of Clostridioides difficile infection: An official clinical practice guideline of the Spanish Society of Chemotherapy (SEQ), Spanish Society of Internal Medicine (SEMI) and the working group of Postoperative Infection of the Spanish Society of Anesthesia and Reanimation (SEDAR).2020Revista Espanola de Quimioterapia
2019 update of the WSES guidelines for management of Clostridioides (Clostridium) difficile infection in surgical patients.2019World Journal of Emergency Surgery
Interventions for the Treatment and Management of Clostridioides Difficile: Clinical Effectiveness and Guidelines.2019CADTH
Clinical practice guidelines for clostridium difficile infection in adults and children: 2017 update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA).2018Clinical Infectious Diseases
Association of Medical Microbiology and Infectious Disease Canada treatment practice guidelines for Clostridium difficile infection.2018Official Journal of the Association of Medical Microbiology and Infectious Disease Canada