Ferric maltol

(Accrufer®)

Ferric maltol

Drug updated on 7/25/2024

Dosage FormCapsule (oral; 30 mg)
Drug ClassIron replacement products
Ongoing and
Completed Studies
ClinicalTrials.gov

Indication

  • Indicated for the treatment of iron deficiency in adults.

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Summary
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  • Ferric maltol (Accrufer) is indicated for the treatment of iron deficiency in adults.
  • The information was derived from two systematic reviews/meta-analyses documents.
  • In a study involving adults and children with inflammatory bowel disease (IBD), oral ferric maltol showed low-certainty evidence of being superior to placebo in resolving iron deficiency anemia (IDA).
  • Compared to intravenous preparations like IV ferric carboxymaltose, which had moderate-certainty evidence suggesting superiority over IV iron sucrose, oral ferric maltol's effectiveness was less favorable but still notable against placebo.
  • Safety profiles indicate that while adverse events were inconsistently reported across studies, there is low-certainty evidence showing little difference in adverse events between oral ferric maltol and placebo.
  • Population considerations highlight varying efficacy and safety among different age groups and stages of IBD; more research is needed specifically targeting fatigue management within these subpopulations.

Product Monograph / Prescribing Information

Document TitleYearSource
Accrufer (ferric maltol) Prescribing Information.2022Shield Therapeutics Inc, North Austin, TX

Systematic Reviews / Meta-Analyses

Document TitleYearSource
Interventions for treating iron deficiency anaemia in inflammatory bowel disease.2021The Cochrane Database of Systematic Reviews
Interventions for fatigue in inflammatory bowel disease.2020The Cochrane Database of Systematic Reviews

Clinical Practice Guidelines