Drug updated on 10/21/2024
Dosage Form | Implant (subdermal: 68 mg) |
Drug Class | Progestin |
Ongoing and Completed Studies | ClinicalTrials.gov |
Indication
- Indicated for use by women to prevent pregnancy.
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Summary
- Nexplanon (etonogestrel) is indicated for use by women to prevent pregnancy.
- This summary is based on the review of four systematic review(s)/meta-analysis(es). [1-4]
- The ENG implant is highly effective as a contraceptive method, with some studies reporting 100% effectiveness and a Pearl Index ranging from 0 to 1.4 in women of reproductive age.
- Compared to other contraceptive methods, the ENG implant has lower one-year continuation rates, with odds ratios of 1.55 and 1.34 when compared to LNG-IUS and Cu-IUD, respectively.
- In women undergoing medical abortion with mifepristone, simultaneous administration of the ENG implant is associated with lower unintended pregnancy rates and higher patient satisfaction compared to delayed administration.
- No complications were observed during insertion, and no side effects were reported during follow-up in young women with chronic psychiatric disorders.
- The ENG implant is generally safe but is associated with abnormal menstrual bleeding, which commonly leads to premature discontinuation in the general population, including young girls post-partum/post-abortion.
- Abnormal menstruation was the most commonly reported side effect, with no significant changes in bone mineral density at one-year follow-up in women of reproductive age.
- ENG implant is effective and safe across diverse populations, including young women with psychiatric disorders, women post-partum/post-abortion, and those undergoing medical abortion, with lower continuation rates observed in general reproductive-age women due to abnormal menstruation.
Product Monograph / Prescribing Information
Document Title | Year | Source |
---|---|---|
Nexplanon (etonogestrel) Prescribing Information. | 2023 | Organon & Co., Jersey City, NJ |
Systematic Reviews / Meta-Analyses
Document Title | Year | Source |
---|---|---|
Alternative insertion site of Nexplanon: description of a case report and systematic review of the literature. | 2022 | Journal of Clinical Medicine |
Safety and benefits of contraceptives implants: a systematic review. | 2021 | Pharmaceuticals |
A systematic review on clinical effectiveness, side-effect profile and meta-analysis on continuation rate of etonogestrel contraceptive implant. | 2021 | Reproductive Health |
Long-acting reversible contraception immediately after medical abortion: systematic review with meta-analyses. | 2020 | Human Reproduction Update |
Clinical Practice Guidelines
Document Title | Year | Source |
---|---|---|
FSRH Guideline (February 2021) Progestogen-only Implant. | 2021 | BMJ Sexual & Reproductive Health |