Summary

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• This summary is based on the review of one systematic review/meta-analysis. ^[1]
• Etelcalcetide's Effectiveness in Hemodialysis Patients: Etelcalcetide was found to lower serum calcification propensity, as measured by the T50 assay, indicating its potential effectiveness in reducing vascular calcification risks in hemodialysis patients.
• Comparative Effectiveness with Other Drugs: Magnesium, phosphate binders, and spironolactone also demonstrated effectiveness in lowering serum calcification propensity in chronic kidney disease (CKD) and hemodialysis patients, with magnesium showing a significant increase in T50 in CKD patients, suggesting reduced vascular calcification risk.
• Effectiveness Across Subgroups: In hemodialysis patients, etelcalcetide, phosphate binders, and spironolactone were effective in reducing calcification propensity, while magnesium was notably beneficial for CKD patients in increasing T50 and reducing calcification risk.
• There is no safety information available in the reviewed studies regarding the safety profile of etelcalcetide or other drugs mentioned, including magnesium, phosphate binders, and spironolactone.