Edoxaban

(Savaysa)

Edoxaban

Drug updated on 11/10/2023

Dosage FormTablet (oral; 15 mg, 30 mg, 60 mg)
Drug ClassFactor Xa inhibitors
Ongoing and Completed StudiesClinicalTrials.gov

Indication

  • To reduce the risk of stroke and systemic embolism (SE) in patients with nonvalvular atrial fibrillation (NVAF).
  • For the treatment of deep vein thrombosis (DVT) and pulmonary embolism (PE) following 5 to 10 days of initial therapy with a parenteral anticoagulant.

Product Monograph / Prescribing Information

Document TitleYearSource
Savaysa (edoxaban) Prescribing Information.2021Daiichi Sankyo, Inc., Basking Ridge, NJ

Systematic Reviews / Meta-Analyses

Document TitleYearSource
Safety and efficacy of direct oral anticoagulants versus vitamin K antagonists in atrial fibrillation electrical cardioversion: An update systematic review and meta-analysis.2023International Journal of Cardiology
Antithrombotic therapy and cardiovascular outcomes after transcatheter aortic valve implantation in patients without indications for chronic oral anticoagulation: a systematic review and network meta-analysis of randomized controlled trials.2023European Heart Journal Cardiovascular Pharmacotherapy
Cost effectiveness of strategies to manage atrial fibrillation in middle- and high-income countries: a systematic review.2023PharmacoEconomics
Oral Anticoagulants for Stroke Prevention in Atrial Fibrillation: A Systematic Review of Economic Evaluations.2023Value in Health Regional Issues
The efficacy and safety of edoxaban versus warfarin in preventing clinical events in atrial fibrillation: A systematic review and meta-analysis.2023The Anatolian Journal of Cardiology
Efficacy and Safety of Renal Function on Edoxaban Versus Warfarin for Atrial Fibrillation: A Systematic Review and Meta-Analysis.2023Medicines
Oral direct thrombin inhibitors or oral factor Xa inhibitors versus conventional anticoagulants for the treatment of deep vein thrombosis2023https://doi.org/10.1002/14651858.CD010956.pub3
Oral direct thrombin inhibitors or oral factor Xa inhibitors versus conventional anticoagulants for the treatment of pulmonary embolism2023The Cochrane database of systematic reviews
Severe Bleeding Risk of Direct Oral Anticoagulants Versus Vitamin K Antagonists for Stroke Prevention and Treatment in Patients with Atrial Fibrillation: A Systematic Review and Network Meta-Analysis2023Cardiovascular drugs and therapy
Non-major bleeding risk of direct oral anticoagulants versus vitamin K antagonists for stroke prevention with atrial fibrillation: a systematic review and network meta-analysis2023European journal of clinical pharmacology
Efficacy and safety of direct oral anticoagulants for the treatment of cancer-associated venous thromboembolism: A systematic review and Bayesian network meta-analysis2023Medicina clinica
Safety outcomes of direct oral anticoagulants in older adults with atrial fibrillation: a systematic review and meta-analysis of (subgroup analyses from) randomized controlled trials2023GeroScience
Risk of stroke and bleeding in relation to hypertension in anticoagulated patients with atrial fibrillation: a meta-analysis of randomised controlled trials.2022Acta Cardiologica
A network meta-analysis of direct factor Xa inhibitors for the treatment of cancer-associated venous thromboembolism.2022Vascular
The use of non-vitamin K oral anticoagulants in dialysis patients—A systematic review.2022Seminars in Dialysis
Cost-effectiveness of New Oral Anticoagulants for the Prevention of Stroke in Patients with Atrial Fibrillation in Low and Middle-Income Countries: A Systematic Review.2022Medical Journal of the Islamic Republic of Iran
Short-term efficacy and safety of edoxaban for venous thromboembolism after total hip or knee arthroplasty: a systematic review and meta-analysis.2022European Review for Medical and Pharmacological Sciences
Optimal stroke preventive strategy for patients aged 80 years or older with atrial fibrillation: a systematic review with traditional and network meta-analysis.2022Age and Ageing
Real-world evidence comparing oral anticoagulants in non-valvular atrial fibrillation: a systematic review and network meta-analysis.2022Future Cardiology
Direct oral anticoagulants for venous thromboembolism in cancer patients: a systematic review and network meta-analysis2022Supportive care in cancer
Efficacy and Safety of Oral Anticoagulants for Atrial Fibrillation Patients With Chronic Kidney Disease: A Systematic Review and Meta-Analysis2022Frontiers in cardiovascular medicine
Direct Oral Anticoagulants vs. Vitamin K Antagonists in Atrial Fibrillation Patients at Risk of Falling: A Meta-Analysis2022Frontiers in cardiovascular medicine
Direct Oral Anticoagulants Compared With Dalteparin for Treatment of Cancer-Associated Thrombosis: A Living, Interactive Systematic Review and Network Meta-analysis2022Mayo Clinic proceedings
Non-vitamin K antagonist oral anticoagulants in venous thromboembolism patients: a meta-analysis of real-world studies2022BMC cardiovascular disorders
Comparative Effects Between Direct Oral Anticoagulants for Acute Venous Thromboembolism: Indirect Comparison From Randomized Controlled Trials2022Frontiers in medicine
Comparative Safety and Efficacy of Eight Antithrombotic Regimens for Patients With Atrial Fibrillation Undergoing Percutaneous Coronary Intervention2022Frontiers in cardiovascular medicine
The association of fracture risk in atrial fibrillation patients and longterm anticoagulant therapy category: a systematic review and meta-analysis. 2021PeerJ
Risk of intracranial hemorrhage with direct oral anticoagulants: a systematic review and meta analysis of randomized controlled trials. 2021Journal of Neurology
Warfarin versus DOACs in the prevention of thromboembolic stroke in patients with Afib. 2021Lynchburg Journal of Medical Science
Major gastrointestinal bleeding risk with direct oral anticoagulants: Does type and dose matter? A systematic review and network meta-analysis. 2021European Journal of Gastroenterology & Hepatology
Ranking the efficacy of anticoagulants for the prevention of venous thromboembolism after total hip or knee arthroplasty: a systematic review and a network meta-analysis. 2021Pharmacological Research
Oral anticoagulant agents in patients with atrial fibrillation and CKD: a systematic review and pairwise network meta-analysis. 2021American Journal of Kidney Diseases
The risk of gastrointestinal bleeding between non-vitamin K antagonist oral anticoagulants and vitamin K antagonists in the Asian atrial fibrillation patients: a meta-analysis. 2021International Journal of Environmental Research and Public Health
The risk of gastrointestinal hemorrhage with non-vitamin K antagonist oral anticoagulants: a network meta-analysis. 2021Medicine
A network meta-analysis comparing osteoporotic fracture among different direct oral anticoagulants and vitamin K antagonists in patients with atrial fibrillation. 2021Journal of Bone Metabolism
Pharmacogenetics of direct oral anticoagulants: a systematic review. 2021Journal of Personalized Medicine
Is chemoprophylaxis required after total knee and total hip arthroplasty in the Asian population? A systematic review and network meta-analysis.2021Thrombosis Research
Safety and efficacy of non-vitamin K antagonist oral anticoagulants in elderly patients with atrial fibrillation: systematic review and meta-analysis of 22 studies and 440 281 patients. 2021Cardiovascular Pharmacotherapy
Risk of stroke and bleeding in relation to hypertension in anticoagulated patients with atrial fibrillation: a meta-analysis of randomised controlled trials. 2021Acta Cardiologica
Efficacy and safety of anticoagulants for postoperative thrombophylaxis in total hip and knee arthroplasty: a PRISMA-compliant Bayesian network meta-analysis. 2021PLoS One
Edoxaban for preventing stroke and systemic embolism in people with non-valvular atrial fibrillation. 2021NICE
The efficacy and safety of edoxaban versus warfarin in preventing clinical events in atrial fibrillation: a systematic review and meta-analysis.2021The Anatolian Journal of Cardiology
Oral anticoagulant agents in patients with atrial fibrillation and CKD: a systematic review and pairwise network meta-analysis.2021American Journal of Kidney Disease
Economic evaluation of direct oral anticoagulants (DOACs) versus vitamin K antagonists (VKAs) for stroke prevention in patients with atrial fibrillation: a systematic review and meta-analysis.2021BMJ Evidence-Based Medicine
A network meta-analysis of non-vitamin K antagonist oral anticoagulants versus warfarin in patients with atrial fibrillation and diabetes mellitus.2021Acta Cardiologica
Effectiveness of Direct Oral Anticoagulants in Obese Adults With Atrial Fibrillation: A Systematic Review of Systematic Reviews and Meta-Analysis 2021Frontiers in cardiovascular medicine
Reasons for discontinuing oral anticoagulation therapy for atrial fibrillation: a systematic review2021Age and ageing
Impact of Age, Sex, and Renal Function on the Efficacy and Safety of Direct Oral Anticoagulants vs. Vitamin K Antagonists for the Treatment of Acute Venous Thromboembolism: A Meta-Analysis of 22,040 Patients 2021Frontiers in cardiovascular medicine
Reappraisal of Non-vitamin K Antagonist Oral Anticoagulants in Atrial Fibrillation Patients: A Systematic Review and Meta-Analysis2021Frontiers in cardiovascular medicine
Real-world safety and efficacy of direct oral anticoagulants in atrial fibrillation: a systematic review and meta-analysis of 605 771 patients2021European heart journal
Comparative efficacy and safety of warfarin care bundles and novel oral anticoagulants in patients with atrial fibrillation: a systematic review and network meta-analysis.2020Scientific Reports
The role of non-vitamin K antagonist oral anticoagulants in Asian patients with atrial fibrillation: A PRISMA-compliant article2020Medicine
Non-vitamin K antagonist oral anticoagulants in Asian patients with atrial fibrillation: evidences from the real-world data2020Heart failure reviews
Direct Oral Anticoagulants for the Treatment of Acute Venous Thromboembolism Associated with Cancer: A Systematic Review and Meta-Analysis2020Thrombosis and haemostasis
Efficacy and Safety of Direct Oral Anticoagulants in Elderly Patients With Atrial Fibrillation: A Network Meta-Analysis 2020Frontiers in medicine
Net Clinical Benefit of Direct Oral Anticoagulants in Patients With Cancer and Venous Thromboembolism: A Systematic Review and Trade-Off Analysis2020Frontiers in cardiovascular medicine
Safety and Efficacy of Oral Anticoagulants Therapies in Patients With Atrial Fibrillation Undergoing Percutaneous Coronary Intervention: A Network Meta-Analysis2020Journal of cardiovascular pharmacology and therapeutics
Non-vitamin K antagonist oral anticoagulants in elderly patients with atrial fibrillation: a systematic review with meta-analysis and trial sequential analysis. 2019Archives of Gerontology and Geriatrics
Direct oral anticoagulants in patients with venous thromboembolism and thrombophilia: a systematic review and meta-analysis2019Journal of thrombosis and haemostasis
Non-vitamin K oral anticoagulants in nonvalvular atrial fibrillation: a network meta-analysis2019Scandinavian cardiovascular journal
Direct Oral Factor Xa Inhibitors for the Treatment of Acute Cancer-Associated Venous Thromboembolism: A Systematic Review and Network Meta-analysis2019Mayo Clinic proceedings
Elderly Bleeding Risk of Direct Oral Anticoagulants in Nonvalvular Atrial Fibrillation: A Systematic Review and Meta-Analysis of Cohort Studies2019Drugs in R&D
Interventions for preventing thromboembolic events in patients with atrial fibrillation: a systematic review.2018Annals of Internal Medicine
Stroke prevention in patients with atrial fibrillation: a systematic review update.2018Agency for Healthcare Research and Quality
Factor Xa inhibitors versus vitamin K antagonists for preventing cerebral or systemic embolism in patients with atrial fibrillation.2018Cochrane Database of Systematic Reviews
Causes of Death in Patients with Venous Thromboembolism Anticoagulated with Direct Oral Anticoagulants: A Systematic Review and Meta-Analysis2018Seminars in thrombosis and hemostasis
Comparison of major bleeding risk in patients with non-valvular atrial fibrillation receiving direct oral anticoagulants in the real-world setting: a network meta-analysis2018Current medical research and opinion

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