Edaravone

(Radicava®)

Edaravone

Drug updated on 5/17/2024

Dosage FormInjection (intravenous; 30 mg/100 mL); Suspension (oral; 105 mg/5 mL)
Drug ClassUnknown mechanism of action
Ongoing and
Completed Studies
ClinicalTrials.gov

Indication

  • Indicated for the treatment of patients with amyotrophic lateral sclerosis (ALS).

Summary
This AI-generated content is provided without warranty and may be inaccurate or outdated; it should be used only as a research starting point, with no liability accepted for reliance on it. Learn more.

  • Edaravone (Radicava) is indicated for the treatment of patients with amyotrophic lateral sclerosis (ALS). It has been shown to slightly slow down the progression in ALSFRS-R score at month 6 compared to placebo and improve survival rates at 18, 24, and 30 months without affecting functional outcomes.
  • Four systematic reviews/meta-analyses provided information on edaravone's effectiveness in real-world settings as well as its long-term efficacy.
  • The use of Radicava did not result in a significant increase in adverse effects compared to placebo or control groups. This was confirmed by all studies reviewed, including a meta-analysis that found no substantial difference in the frequency of adverse events or serious adverse events between edaravone and placebo groups.
  • Compared to other drugs for ALS treatment, preliminary inference suggests that Radicava may offer benefits such as slowing disease progression and improving survival rates without increasing the risk of severe side effects.
  • Detailed subgroup analyses such as age, gender, or specific ALS phenotypes were not prominently discussed across the studies, but there was an emphasis on the need for further high-quality prospective clinical trials. These trials might provide more detailed subgroup considerations, especially how disease stage could influence treatment outcomes.
  • While Radicava shows potential benefits in improving survival rates and slowing disease progression among ALS patients without leading to a significant increase in adverse events when compared with placebos, it is important that further research be conducted to establish the drug's long-term efficacy and understand its impact on various subgroups to confirm these preliminary findings.