Droxidopa

(Northera®)

Droxidopa

Drug updated on 9/4/2024

Dosage FormCapsules (oral: 100 mg, 200 mg, 300 mg)
Drug ClassSynthetic amino acid analogs
Ongoing and
Completed Studies
ClinicalTrials.gov

Indication

  • Indicated for the treatment of orthostatic dizziness and light-headedness or the “feeling that you are about to black out” in adult patients with symptomatic neurogenic orthostatic hypotension (nOH) caused by primary autonomic failure (Parkinson's disease [PD], multiple system atrophy, and pure autonomic failure), dopamine beta-hydroxylase deficiency, and non-diabetic autonomic neuropathy.

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Summary
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  • Northera (droxidopa) is indicated for the treatment of orthostatic dizziness and light-headedness, or the "feeling that you are about to black out," in adult patients with symptomatic neurogenic orthostatic hypotension (nOH) caused by primary autonomic failure (Parkinson's disease [PD], multiple system atrophy, and pure autonomic failure), dopamine beta-hydroxylase deficiency, and non-diabetic autonomic neuropathy.
  • This summary is based on the review of two systematic review(s)/meta-analysis(es). [1-2]
  • Pharmacologic treatments, including droxidopa, were effective in reducing Postural Orthostatic Tachycardia Syndrome (POTS) symptoms and increasing orthostatic tolerance, although the studies had small sample sizes (10-50 subjects).
  • Droxidopa, midodrine, and pyridostigmine were noted as effective in preventing Orthostatic Hypotension (OH), with clonidine and beta-blockers used to treat Supine Hypertension (SH) without causing significant hypotension.
  • No significant differences in effectiveness among different population types or subgroups were reported in the studies.
  • There is no safety information available in the reviewed studies.
  • There is no population types or subgroups information available in the reviewed studies.

Product Monograph / Prescribing Information

Document TitleYearSource
Northera (droxidopa) prescribing information. 2019Lundbeck, Deerfield, IL

Systematic Reviews / Meta-Analyses