Summary

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• Dasiglucagon (Zegalogue) is indicated for the treatment of severe hypoglycemia in pediatric and adult patients with diabetes aged 6 years and above. It has a comparable safety profile to native glucagon, but shows significant improvement in reducing recovery time from hypoglycemic events.
• Two studies investigate Dasiglucagon's safety and efficacy compared to conventional glucagon, placebo, or oral glucose.
• The first study reveals that Dasiglucagon significantly outperforms placebo by decreasing the recovery time of blood glucose levels. Similarly, it also indicates superior efficacy over oral glucose.
• Although no explicit subgroup distinctions are detailed in these studies, they suggest general effectiveness and safety across populations suffering from Type 1 Diabetes Mellitus (T1DM), including both pediatric and adult patients aged 6 years and above.
• Compared directly to conventional glucagon, Dasiglucagon offers potential practical advantages due to its stability, which does not require reconstitution; however, this feature was not quantified within the provided efficacy metrics.
• Overall, based on these two systematic reviews/meta-analyses: Dasiglucagon proves effective for managing severe hypoglycemia, particularly where rapid recovery is critical.