Chemical Nameramucirumab
Dosage FormInjection (intravenous; 100 mg/10 mL (10 mg/mL), 500 mg/50 mL (10 mg/mL))
Drug ClassReceptor antagonists
SystemDigestive, Respiratory
CompanyEli Lilly and Company
Approval Year2014


  • As a single agent or in combination with paclitaxel, for treatment of advanced or metastatic gastric or gastro-esophageal junction adenocarcinoma with disease progression on or after prior fluoropyrimidine- or platinum-containing chemotherapy.
  • In combination with erlotinib, for first-line treatment of metastatic non-small cell lung cancer with epidermal growth factor receptor (EGFR) exon 19 deletions or exon 21 (L858R) mutations.
  • In combination with docetaxel, for treatment of metastatic non-small cell lung cancer with disease progression on or after platinum-based chemotherapy. Patients with EGFR or ALK genomic tumor aberrations should have disease progression on FDA-approved therapy for these aberrations prior to receiving CYRAMZA.
  • In combination with FOLFIRI, for the treatment of metastatic colorectal cancer with disease progression on or after prior therapy with bevacizumab, oxaliplatin, and a fluoropyrimidine.
  • As a single agent, for the treatment of hepatocellular carcinoma in patients who have an alpha fetoprotein of ≥400 ng/mL and have been treated with sorafenib.
Last updated on 4/20/2021

More on this drug: Clinical Trials

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Document TitleYearSource
Cyramza (ramucirumab) Prescribing Information 2014Eli Lilly and Company, Indianapolis, IN
Document TitleYearSource
Comparative efficacy and safety of anti-PD-1/PD-L1 immune checkpoint inhibitors for refractory or relapsed advanced non-small-cell lung cancer—A systematic review and network meta-analysis.2021Cancers
Systemic therapy and sequencing options in advanced hepatocellular carcinoma: A Systematic review and network meta-analysis. 2020JAMA Oncology
Optimizing survival and the changing landscape of targeted therapy for intermediate and advanced hepatocellular carcinoma: A systematic review. 2020Journal of the National Cancer Institute
Efficacy and safety of epidermal growth factor receptor (EGFR) inhibitors plus antiangiogenic agents as first-line treatments for patients with advanced EGFR-mutated non-small cell lung cancer: A meta-analysis.2020Frontiers in Oncology
Role of systemic treatment for advanced/metastatic gastric carcinoma in the third-line setting: A bayesian network analysis.2020Frontiers in Oncology
Systemic therapy for previously treated advanced gastric cancer: A systematic review and network meta-analysis. 2019Critical Reviews in Oncology / Hematology
Comparative survival benefit of currently licensed second or third line treatments for epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) negative advanced or metastatic non-small cell lung cancer: a systematic review and secondary analysis of trials.2019BMC Cancer
Ramucirumab safety in East Asian patients: A meta-analysis of six global, randomized, double-blind, placebo controlled, phase III clinical trials.2018Journal of Global Oncology
Treatment outcome of anti-angiogenesis through VEGF-pathway in the management of gastric cancer: a systematic review of phase II and III clinical trials.2018BMC Research Notes
Palliative chemotherapy and targeted therapies for esophageal and gastroesophageal junction cancer. 2017The Cochrane Database of Systematic Reviews
Meta-analysis of individual patient safety data from six randomized, placebo-controlled trials with the antiangiogenic VEGFR2-binding monoclonal antibody ramucirumab.2017Annals of Oncology
Incidence and risk of cardiotoxicity in cancer patients treated with targeted therapies. 2017Cancer treatment reviews
Anti-angiogenic therapy in patients with advanced gastric and gastroesophageal junction cancer: A systematic review.2017Cancer Research and Treatment
Risk of gastrointestinal perforation in cancer patients receiving ramucirumab: a meta-analysis of randomized controlled trials. 2016Journal of Chemotherapy
Controlling angiogenesis in gastric cancer: A systematic review of anti-angiogenic trials. 2016Cancer Letters
Short-term and long-term efficacy of 7 targeted therapies for the treatment of advanced hepatocellular carcinoma: a network meta-analysis.2016Medicine
Second- and third-line systemic therapy in patients with advanced esophagogastric cancer: a systematic review of the literature.2016Cancer Metastasis Reviews