Summary

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• This summary is based on the review of one randomized controlled trial. ^[1]
• Cefepime/enmetazobactam achieved an overall treatment success rate of 79.1% (273/345) compared to 58.9% (196/333) for piperacillin/tazobactam, with a between-group difference of 21.2% (95% confidence interval (CI), 14.3% to 27.9%).
• Cefepime/enmetazobactam met the criteria for noninferiority and demonstrated superiority over piperacillin/tazobactam in the primary outcome, defined as clinical cure combined with microbiological eradication in patients with complicated urinary tract infections or acute pyelonephritis.
• Treatment-emergent adverse events occurred in 50.0% of patients receiving cefepime/enmetazobactam (258/516) and 44.0% of those receiving piperacillin/tazobactam (228/518). Most adverse events were mild to moderate in severity (89.9% for cefepime/enmetazobactam vs. 88.6% for piperacillin/tazobactam).
• A higher percentage of patients discontinued cefepime/enmetazobactam due to adverse events compared to piperacillin/tazobactam (1.7% vs. 0.8%).
• There is no population types or subgroups information available in the reviewed studies.