Cannabidiol

(Epidiolex)

Cannabidiol

Drug updated on 11/16/2023

Dosage FormSolution (oral; 100 mg/mL)
Drug ClassUnknown mechanism of action
Ongoing and Completed StudiesClinicalTrials.gov

Indication

  • For the treatment of seizures associated with Lennox-Gastaut syndrome, Dravet syndrome, or Tuberous sclerosis complex in patients 1 year of age and older.

Product Monograph / Prescribing Information

Document TitleYearSource
Epidiolex (cannabidiol) Prescribing Information.2022Greenwich Biosciences, Inc., Carlsbad, CA

Systematic Reviews / Meta-Analyses

Document TitleYearSource
Cannabidiol-associated hepatotoxicity: A systematic review and meta-analysis.2023Journal of Internal Medicine
Adverse Events of Cannabidiol Use in Patients With Epilepsy A Systematic Review and Meta-analysis.2023Jama Network
Cannabinoids to improve health-related quality of life in patients with neurological or oncological disease: a meta-analysis.2023Cannabis and Cannabinoid Research
Efficacy and safety of adjunctive antiseizure medications for Dravet syndrome: a systematic review and network meta-analysis.2022Frontiers in Pharmacology
Short-term and long-term efficacy and safety of antiseizure medications in Lennox Gastaut syndrome: a network meta-analysis.2022Seizure: European Journal of Epilepsy
Anti-seizure medications for Lennox-Gastaut syndrome. 2021Cochrane Database of Systematic Reviews
Highly purifed cannabidiol for epilepsy treatment: a systematic review of epileptic conditions beyond Dravet syndrome and Lennox–Gastaut syndrome. 2021CNS Drugs
Australian public assessment report for cannabidiol. 2021Australian Government: Department of Health
Efficacy and safety of medical cannabinoids in children: a systematic review and meta-analysis.2021Scientific Reports
Adjunctive cannabidiol in patients with Dravet syndrome: a systematic review and meta-analysis of efficacy and safety.2020CNS Drugs
Cannabis-based products for pediatric epilepsy: an updated systematic review. 2020Seizure
Cannabis-based products for pediatric epilepsy: a systematic review.2019Epilepsia
Efficacy and safety of cannabidiol in epilepsy: a systematic review and meta‑analysis.2018Drugs
Efficacy and safety of adjunctive cannabidiol in patients with Lennox-Gastaut syndrome: a systematic review and meta-analysis.2018CNS Drugs

Clinical Practice Guidelines