Brivaracetam

(Briviact®)

Brivaracetam

Drug updated on 11/16/2023

Dosage FormTablet (oral; 10 mg, 25 mg, 50 mg, 75 mg, 100 mg); Solution (oral; 10 mg/mL); Injection (intravenous; 50 mg/ 5 mL)
Drug ClassAnticonvulsants
Ongoing and
Completed Studies
ClinicalTrials.gov

Indication

  • Indicated for the treatment of partial-onset seizures in patients 1 month of age and older.

Product Monograph / Prescribing Information

Document TitleYearSource
Briviact (brivaracetam) Prescribing Information.2023UCB, Inc., Smyrna, GA

Systematic Reviews / Meta-Analyses

Document TitleYearSource
Safety and efficacy of brivaracetam in children epilepsy: a systematic review and meta-analysis.2023Frontiers in Neurology
Brivaracetam add-on therapy for drug-resistant epilepsy. 2022Cochrane Database of Systematic Reviews
Third-generation antiseizure medications for adjunctive treatment of focal-onset seizures in adults: a systematic review and network meta-analysis2022Drugs
Anti-seizure medications and efficacy against focal to bilateral tonic-clonic seizures: a systematic review with relevance for SUDEP Prevention.2021Epilepsy & Behaviour
Brivaracetam: How well does it fare as an anti-epileptic? A review. 2021Neurology India
A meta-analysis: efficacy and safety of anti-epileptic drugs prescribed in Korea as monotherapy and adjunctive treatment for patients with focal epilepsy. 2021Translational and Clinical Pharmacy
Suicidality Risk of Newer Antiseizure Medications: A Meta-analysis.2021JAMA Neurology
Therapeutic options for patients with refractory status epilepticus in palliative settings or with a limitation of life-sustaining therapies: a systematic review.2020CNS Drugs
Safety and tolerability of adjunctive brivaracetam in epilepsy: In-depth pooled analysis.2020Epilepsy and Behavior
Intravenous brivaracetam in the treatment of status epilepticus: a systematic review.2019CNS Drugs
The medical treatment of epilepsy in the elderly: A systematic review and meta-analysis.2019Epilepsia
Efficacy and safety of antiepileptic drugs for refractory partial-onset epilepsy: a network meta-analysis.2018Journal of Neurology

Clinical Practice Guidelines

Document TitleYearSource
Epilepsies in children, young people and adults. 2022NICE
Clinical guidelines for the management of epilepsy.2020The Epilepsy Research Program of the Ontario Brain institute