Drug updated on 5/6/2024
Dosage Form | Injection (subcutaneous; 18 mg/0.45 mL, 28 mg/0.7 mL, 40 mg/mL, 80 mg/0.8 mL) |
Drug Class | Tissue nonspecific alkaline phosphatases |
Ongoing and Completed Studies | ClinicalTrials.gov |
Indication
- Indicated for the treatment of patients with perinatal/infantile- and juvenile-onset hypophosphatasia (HPP).
Summary
- Asfotase alfa (Strensiq) is used for the treatment of patients with perinatal/infantile- and juvenile-onset hypophosphatasia (HPP).
- Three systematic reviews/meta-analyses were reviewed, providing insights into the effectiveness and safety of asfotase alfa in treating HPP.
- The first study found that enzyme replacement therapy using asfotase alfa effectively treats infants, children, and adults suffering from HPP by increasing their lifespan.
- A post hoc analysis pooled data from two phase 2 studies to investigate clinical outcomes with asfotase alfa in relation to ALPL variant state; it was found that both biallelic and monoallelic variants showed similar pretreatment baseline clinical characteristics but those with biallelic variants had significantly higher Baseline PPi and PLP levels than monoallelic variants.
- Despite these differences at baseline between biallelic or monoallelic variant states, treatment with asfotase alfa for up to 5 years normalized TNSALP substrate concentrations and improved functional outcomes without clear differences between these groups.
- The third review emphasized the significant morbidity associated with HPP due to loss of function mutations in the ALPL gene causing reductions in alkaline phosphatase activity; pharmacologic intervention such as Strensiq can result in significant clinical improvement across various manifestations including musculoskeletal, renal, dental respiratory,and neurologic symptoms related to this disorder.
Product Monograph / Prescribing Information
Document Title | Year | Source |
---|---|---|
Strensiq (asfotase alfa) Prescribing Information. | 2020 | Alexion Pharmaceuticals, Inc., Boston, MA |
Systematic Reviews / Meta-Analyses
Document Title | Year | Source |
---|---|---|
Effect of asfotase alfa in the treatment of hypophosphatasia- a systematic review. | 2023 | Journal of Pharmacy & Bioallied Sciences |
Investigation of ALPL variant states and clinical outcomes: an analysis of adults and adolescents with hypophosphatasia treated with asfotase alfa. | 2021 | Molecular Genetics and Metabolism |
Hypophosphatasia: Canadian update on diagnosis and management. | 2019 | Osteoporosis International |
Clinical Practice Guidelines
Document Title | Year | Source |
---|---|---|
Emerging therapies for the treatment of rare pediatric bone disorders. | 2022 | Frontiers in Pediatrics |
Clinical practice guidelines for hypophosphatasia. | 2020 | Clinical Pediatric Endocrinology |