Summary

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• Ansuvimab-zykl (Ebanga) is indicated for the treatment of infection caused by Zaire ebolavirus in adult and pediatric patients, including neonates born to a mother who is RT-PCR positive for Zaire ebolavirus infection. It has been shown to have a mortality rate of 35.1% when administered as a 50 mg/kg single IV dose.
• Information was derived from two systematic reviews/meta-analyses that focused on comparing Ebanga with other drugs used in treating Ebola virus disease (EVD), such as INMAZEB, remdesivir, and ZMapp.
• In terms of efficacy compared to other treatments, INMAZEB showed superior results with its components REGN-EB3 and mAb114 significantly reducing mortality compared to standard care, while remdesivir showed uncertain benefits concerning mortality reduction.
• Regarding safety profile comparisons across these drugs, fever, tachycardia, diarrhea, vomiting, hypotension, tachypnea, and chills were common adverse effects observed; however, there might be little or no difference in the prevalence of serious adverse events across all drugs, except for high certainty in REGN-EB3 reducing mortality compared with others like ZMapp and remdesivir.
• Documents did not specify distinct population types or subgroup considerations beyond general adult and pediatric patient populations, but it's noted that Ebanga may be preferentially chosen for patients with cardiovascular complications where other treatments pose a higher risk.
• Ebanga remains an effective choice behind INMAZEB based on provided data regarding safety profiles & effectiveness at reducing EVD-related mortalities, making it a potentially suitable alternative, especially among specific patient groups like those having cardiovascular concerns.