Anacaulase-bcdb

(NexoBrid®)

Anacaulase-bcdb

Drug updated on 10/24/2024

Dosage FormGel (topical; 8.8%)
Drug ClassProteolytic enzymes
Ongoing and
Completed Studies
ClinicalTrials.gov

Indication

  • Indicated for eschar removal in adults and pediatric patients with deep partial thickness and/or full thickness thermal burns

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Summary
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  • This summary is based on the review of one systematic review(s)/meta-analysis(es). [1]
  • Nexobrid® is effective for debridement of deep burns, leading to improved functional and cosmetic outcomes, reduced scarring, and enhanced quality of life, with faster healing times and reduced hospital stays.
  • High patient satisfaction is reported, supported by enhanced analgosedation and/or locoregional anesthesia protocols, with fewer cases of sepsis and blood transfusions, and prevention of compartment syndrome.
  • The review does not specify population subgroups or provide comparative effectiveness data against other treatments.
  • Nexobrid® is described as a safe treatment for eschar removal, with no strong evidence of adverse events like coagulopathy or burn wound infection reported in the reviewed studies.
  • High patient satisfaction related to pain management protocols, involving enhanced analgosedation and/or locoregional anesthesia, further supports a favorable safety profile.
  • There is no population types or subgroups information available in the reviewed documents.

Product Monograph / Prescribing Information

Document TitleYearSource
NexoBrid (anacaulase-bcdb) Prescribing Information.2024Vericel Corporation, Cambridge, MA

Systematic Reviews / Meta-Analyses