Drug updated on 5/17/2024
Dosage Form | Capsule (oral; 100 mg) |
Drug Class | Kinase inhibitors |
Ongoing and Completed Studies | ClinicalTrials.gov |
Indication
- Indicated for the treatment of adult patients with mantle cell lymphoma (MCL) who have received at least one prior therapy.
- Indicated for the treatment of adult patients with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL).
Latest News
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Summary
- Acalabrutinib (Calquence) is recommended for the treatment of adult patients with mantle cell lymphoma (MCL) and chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), especially those who have undergone at least one previous therapy.
- Three studies were evaluated, two focusing on CLL/SLL and one on MCL, providing insights into acalabrutinib's safety and effectiveness compared to other options.
- Regarding effectiveness, acalabrutinib demonstrates significant improvement in progression-free survival over standard treatments including bendamustine + rituximab and chlorambucil-based therapy among others. It also shows a higher overall response rate than ibrutinib and other targeted therapies such as bortezomib, lenalidomide, temsirolimus in the relapsed/refractory MCL setting.
- Acalabrutinib has a favorable safety profile with fewer high-grade adverse events compared to treatments within its class like ibrutinib or zanubrutinb. Adverse events mainly include cytopenia and hypertension but are generally manageable.
- Individuals younger than 65 years or those treated with combination therapy involving BTKi displayed higher effectiveness according to the studies. Treatment-naive individuals especially benefit from this drug, particularly for CLL/SLL indication.
- The overall analysis underscores acalabrutinib's valuable role in treating these complex hematologic malignancies, advocating for its usage based on current evidence, especially in patients who have received prior therapy or in combination treatment settings.
Product Monograph / Prescribing Information
Document Title | Year | Source |
---|---|---|
Calquence (acalabrutinib) Prescribing Information. | 2022 | AstraZeneca Pharmaceuticals LP, Wilmington, DE |
Systematic Reviews / Meta-Analyses
Clinical Practice Guidelines
Document Title | Year | Source |
---|---|---|
Chronic lymphocytic leukemia. | 2022 | Alberta Health Services |
Chronic lymphocytic leukemia/small lymphocytic lymphoma, version 4.2020, NCCN clinical practice guidelines in oncology. | 2020 | Journal of the National Comprehensive Cancer Network |
Chronic lymphocytic leukaemia: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. | 2020 | Annals of Oncology |