Abobotulinumtoxin A

(Dysport®)

Abobotulinumtoxin A

Drug updated on 7/25/2024

Dosage FormInjection (intramuscular; 300 units, 500 units)
Drug ClassMultiple
Ongoing and
Completed Studies
ClinicalTrials.gov

Indication

  • Indicated for the treatment of cervical dystonia in adults.
  • Indicated for the temporary improvement in the appearance of moderate to severe glabellar lines associated with procerus and corrugator muscle activity in adults < 65 years of age.
  • Indicated for the treatment of spasticity in patients 2 years of age and older.

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Summary
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  • Abobotulinumtoxin A (Dysport) is indicated for the treatment of cervical dystonia in adults, temporary improvement in the appearance of moderate to severe glabellar lines associated with procerus and corrugator muscle activity in adults under 65 years of age, and treatment of spasticity in patients 2 years of age and older.
  • The information was derived from a total of 8 systematic reviews/meta-analyses documents.
  • For neurogenic detrusor overactivity (NDO), trends favored higher doses of abobotulinumtoxin A compared to onabotulinumtoxinA but required confirmatory studies due to limited evidence.
  • In cosmetic applications for facial aesthetics, high patient satisfaction was observed across various subgroups, including different ages and sexes within adult populations under 65 years old.
  • Consistent efficacy and safety profiles were noted for hyperhidrosis treatments across multiple types, such as axillary, palmar, and forehead hyperhidrosis among adult populations without serious adverse events reported.
  • Pediatric lower limb spasticity showed significant efficacy advantages over other botulinum toxins like onabotulinumtoxinA with comparable rates of adverse events.

Product Monograph / Prescribing Information

Document TitleYearSource
Dysport (abobotulinumtoxin A) Prescribing Information.2020Ipsen Biopharmaceuticals, Inc., Cambridge, Fort Worth, TX

Systematic Reviews / Meta-Analyses

Clinical Practice Guidelines

Document TitleYearSource
Oscar clinical guideline: botulinum toxin.2017OSCAR