Zuranolone

(Zurzuvae®)

Zuranolone

Drug updated on 4/17/2024

Dosage FormCapsule (oral; 20 mg, 25 mg, 30 mg)
Drug ClassNeuroactive steroid gamma-aminobutyric acid modulators
Ongoing and
Completed Studies
ClinicalTrials.gov

Indication

  • Indicated for the treatment of postpartum depression in adults.

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Summary
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  • Zuranolone (Zurzuvae) is indicated for the treatment of postpartum depression in adults. It demonstrates significant improvements in patients with major depressive disorder and postpartum depression, characterized by reduced Hamilton Depression Rating Scale scores and increased response rates.
  • The study was based on five systematic reviews/meta-analyses that evaluated the efficacy, safety, and tolerability of Zuranolone compared to other treatments such as brexanolone and traditional medications like estradiol and paroxetine.
  • Compared to these alternatives, Zuranolone has proven effective, especially for patients who have not responded well to other treatments. While both estradiol and brexanolone were more effective than a placebo, Zuranolone maintains a competitive stance due to its broader safety profile.
  • However, it is important to note that treatment with Zuranolone is associated with an increased incidence of adverse events including somnolence, dizziness, and sedation, which necessitates monitoring during its use.
  • In terms of tolerability when compared to brexanolone, Zuranolone's performance varies depending on dose levels but generally falls within acceptable ranges or better, thus making it a somewhat preferable choice.
  • Current studies primarily focus on adult populations suffering from major depressive disorder (MDD) or postpartum depression (PPD), with interest in expanding research into diverse population subsets, including children and adolescents. This expansion aims to optimize treatment regimens across different doses and durations, thereby improving overall effectiveness while ensuring patient safety.