Drug updated on 9/4/2024
Dosage Form | Inhalation (oral; 1000 mL) |
Drug Class | Hyperpolarized contrast agents |
Ongoing and Completed Studies | ClinicalTrials.gov |
Indication
- Indicated for use with magnetic resonance imaging (MRI) for evaluation of lung ventilation in adults and pediatric patients aged 12 years and older.
Latest News
Summary
- Xenoview (xenon xe 129 hyperpolarized) is indicated for use with magnetic resonance imaging (MRI) for the evaluation of lung ventilation in adults and pediatric patients aged 12 years and older.
- This summary is based on the review of three systematic review(s)/meta-analysis(es). 3. [1-3]
- Xe MRI in Long-COVID patients: 129Xe MRI identified persistent gas exchange and ventilation abnormalities up to one year post-COVID-19 infection, even when other diagnostic tests (pulmonary function tests, chest CT scans) appeared normal or nearly normal.
- Neuroprotective effects in brain injuries: Xenon showed significant neuroprotective effects in preclinical studies of brain injuries, with effect sizes of 34.1% (95% CI, 24.7-43.6%) and 27.4% (95% CI, 11.5-43.3%), including CPB models, and was significantly more protective than argon.
- Hyperpolarized gas MRI in Cystic Fibrosis patients: Hyperpolarized gas MRI, including xenon-129, was more sensitive than FEV1 in detecting structural and functional lung abnormalities in CF patients, showing responsiveness to treatments and potential utility in early disease detection and longitudinal monitoring.
- There is no safety information available in the reviewed studies.
- There is no population types or subgroups information available in the reviewed studies.
Product Monograph / Prescribing Information
Document Title | Year | Source |
---|---|---|
Xenoview (xenon Xe 129 hyperpolarized) prescribing information. | 2022 | Polarean, Inc., Durham, NC |
Systematic Reviews / Meta-Analyses
Document Title | Year | Source |
---|---|---|
Review of hyperpolarized pulmonary functional 129Xe MR for long-COVID. | 2024 | Journal of Magnetic Resonance Imaging |
Neuroprotection by the noble gases argon and xenon as treatments for acquired brain injury: a preclinical systematic review and meta-analysis. | 2022 | British Journal of Anaesthesia |
Is hyperpolarised gas magnetic resonance imaging a valid and reliable tool to detect lung health in cystic fibrosis patients? A cosmin systematic review. | 2021 | Journal of Cystic Fibrosis |