Rivaroxaban

(Xarelto®)

Xarelto®

Drug updated on 12/11/2024

Dosage FormTablet (oral; 2.5 mg, 10 mg, 15 mg, 20 mg); suspension (oral; 1 mg/mL)
Drug ClassFactor Xa inhibitors
Ongoing and
Completed Studies
ClinicalTrials.gov

Indication

  • Indicated to reduce risk of stroke and systemic embolism in nonvalvular atrial fibrillation
  • Indicated for treatment of deep vein thrombosis (DVT)
  • Indicated for treatment of pulmonary embolism (PE)
  • Indicated to reduce the risk of recurrence of DVT or PE
  • Indicated as prophylaxis of DVT, which may lead to PE in patients undergoing knee or hip replacement surgery
  • Indicated as prophylaxis of venous thromboembolism (VTE) in acutely ill medical patients
  • Indicated to reduce the risk of major cardiovascular events in patients with coronary artery disease (CAD)
  • Indicated to reduce the risk of major thrombotic vascular events in patients with peripheral artery disease (PAD), including patients after recent lower extremity revascularization due to symptomatic PAD
  • Indicated for the treatment of VTE and reduction in the risk of recurrent VTE in pediatric patients from birth to less than 18 years
  • Indicated as thromboprophylaxis in pediatric patients 2 years and older with congenital heart disease after the Fontan procedure.

Latest News

loading GIF

Summary
This AI-generated content is provided without warranty, with no liability accepted for reliance on it. Learn more.

  • This summary is based on the review of 172 systematic review(s)/meta-analysis(es). [1-171]
  • Venous Thromboembolism (VTE) Prophylaxis in Non-Major Orthopedic Surgery: Rivaroxaban showed no statistically significant difference in preventive effect against VTE compared to low-molecular-weight heparin (LMWH) (relative risk (RR) 0.80; 95% confidence interval (CI) 0.31 to 2.07).
  • Coronary Artery Disease (CAD) Management: Low-dose rivaroxaban (2.5 mg) significantly decreased all-cause mortality (hazard ratio (HR) 0.88; 95% CI 0.81-0.95), myocardial infarction (HR 0.81; 95% CI 0.70-0.94), and stroke (HR 0.61; 95% CI 0.49-0.76) compared to aspirin alone.
  • Atrial Fibrillation (AF) in End-Stage Kidney Disease (ESKD): Factor Xa inhibitors, including rivaroxaban, were associated with a lower risk of stroke or systemic embolism (SSE) compared to vitamin K antagonists (VKAs) (OR 0.37; 95% CI 0.15-0.93).
  • Residual Risk in Atherosclerotic Cardiovascular Disease: Rivaroxaban combined with aspirin reduced cardiovascular events and ischemic stroke compared to aspirin alone (HR 0.76; 95% CI 0.66-0.86).
  • There is no statistically significant difference in bleeding events when comparing rivaroxaban to LMWH in non-major orthopedic surgery (RR 1.15; 95% CI 0.75 to 1.76).
  • Low-dose rivaroxaban combined with aspirin significantly increased the risk of major bleeding compared to aspirin alone (HR 1.66; 95% CI 1.40-1.97).
  • There were no significant differences in major bleeding incidents when comparing rivaroxaban to aspirin in patients undergoing total hip arthroplasty (THA) and total knee arthroplasty (TKA).
  • In patients with atrial fibrillation and end-stage kidney disease (ESKD), there was no significant difference in major bleeding events between factor Xa inhibitors and VKAs (HR 0.87; 95% CI 0.62-1.22).
  • In the context of isolated superficial vein thrombosis (iSVT), rivaroxaban demonstrated superior outcomes in preventing thrombotic complications compared to LMWH.

Product Monograph / Prescribing Information

Document TitleYearSource
Xarelto (rivaroxaban) Prescribing Information.2023Janssen Pharmaceuticals, Inc., Titusville, NJ

Systematic Reviews / Meta-Analyses

Document TitleYearSource
Effectiveness and safety of rivaroxaban or low-molecular-weight heparin in non-major orthopedic surgery: a meta-analysis of randomized controlled trials2024Journal Of Orthopaedic Surgery And Research
Effectiveness of low-dose rivaroxaban in preventing recurrent major adverse cardiovascular events in coronary artery disease: a systematic review and meta-analysis of randomized controlled trials2024Coronary Artery Disease
Comparative efficacy of aspirin versus direct oral anticoagulants for venous thromboembolism prophylaxis following primary total hip arthroplasty or total knee arthroplasty: A systematic review and meta-analysis of randomised controlled trials2024Journal Of Experimental Orthopaedics
Factor Xa Inhibitors Versus Vitamin K Antagonists in Atrial Fibrillation Patients with End-Stage Kidney Disease on Dialysis: A Meta-Analysis2024Clinical And Applied Thrombosis/Hemostasis : Official Journal Of The
Antithrombotic prophylaxis following total knee arthroplasty: a level I Bayesian network meta-analysis2024European Journal Of Orthopaedic Surgery & Traumatology : Orthopedie Traumatologie
Anticoagulants for the treatment of isolated lower limb superficial vein thrombosis a Bayesian network meta-analysis of randomized controlled trials2024Thrombosis Research
Efficacy and safety of drugs in residual cardiovascular risk: A systematic review of the literature2024International Journal Of Cardiology. Cardiovascular Risk And Prevention
Evaluating Renal Benefits of Rivaroxaban Versus Vitamin K Antagonists in Atrial Fibrillation: A Systematic Review and Meta-analysis of Real-world Evidence2024European Cardiology
Effectiveness of Novel Oral Anticoagulants Versus Warfarin in Patients With Atrial Fibrillation: A Systematic Review and Meta-Analysis2024Cureus
Efficacy and safety of antithrombotic therapy for preventing and treating pediatric thromboembolic disease: a systematic review2024Scientific Reports
Effectiveness and safety of rivaroxaban for anticoagulation therapy in COVID-19: A meta-analysis of randomized controlled trials2024Saudi Medical Journal
Safety and efficacy of direct oral anticoagulants in comparison to warfarin in obese patients with atrial fibrillation: A systematic review and meta-analysis2024Health Science Reports
Efficacy and Safety of Combination Therapy with Low-Dose Rivaroxaban in Patients with Cardiovascular Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials2024Journal Of Clinical Medicine
Comparing Anticoagulation Strategies for Venous Thromboembolism Associated With Active Cancer: A Systematic Review and Meta-Analysis2024Cardiooncology
Efficacy and Safety of Different Dosing Regimens of Rivaroxaban in Patients With Atrial Fibrillation for Stroke Prevention: A Systematic Review and Meta-Analysis2024Cureus
Non-vitamin-K-antagonist oral anticoagulants (NOACs) after acute myocardial infarction: a network meta-analysis2024The Cochrane Database Of Systematic Reviews
Antithrombotic prophylaxis following total hip arthroplasty: a level I Bayesian network meta-analysis2024Journal Of Orthopaedics And Traumatology : Official Journal Of The Italian
Risk factors for anticoagulant-associated gastrointestinal hemorrhage: a systematic review and meta-analysis2024The Korean Journal Of Internal Medicine
Comparative safety and effectiveness of non-vitamin K oral anticoagulants versus warfarin in patients with non-valvular atrial fibrillation: A network meta-analysis2024Journal Of The Formosan Medical Association
Antithrombotic Prophylaxis with Rivaroxaban in Patients with Prehospital COVID-19: A Meta-analysis of Two Placebo-Controlled Trials2024Thrombosis And Haemostasis
Safety outcomes of direct oral anticoagulants in older adults with atrial fibrillation: a systematic review and meta-analysis of (subgroup analyses from) randomized controlled trials2024Geroscience
Dual-pathway Inhibition with Low-dose Aspirin and Rivaroxaban versus Aspirin Monotherapy in Patients with Coronary Artery Disease and Peripheral Artery Disease: Systematic Literature Review and Meta-analysis2024European Cardiology
Comparison of efficacy and safety between aspirin and oral anticoagulants for venous thromboembolism prophylaxis after major orthopaedic surgery: a meta-analysis of randomized clinical trials2023Frontiers In Pharmacology
Anticoagulant drugs for patients with atrial fibrillation on dialysis: a systematic analysis and network meta-analysis2023Frontiers In Pharmacology
Comparison efficacy and safety of different antiplatelet or anticoagulation drugs in chronic coronary syndromes patients: A Bayesian network meta-analysis2023Medicine
Efficacy and Safety of Direct Oral Anticoagulants for Stroke Prevention in Older Patients With Atrial Fibrillation: A Network Meta-Analysis of Randomized Controlled Trials2023Journal Of The American Heart Association
Bleeding and thromboembolic risk in patients under anticoagulant therapy receiving oral surgery: a systematic review2023Medicine And Pharmacy Reports
Comparisons of effectiveness and safety between on-label dosing, off-label underdosing, and off-label overdosing in Asian and non-Asian atrial fibrillation patients treated with rivaroxaban: a systematic review and meta-analysis of observational studies2023Europace
Comparison of Different Chronic Maintenance Antithrombotic Strategies in Patients with Coronary Artery Disease: A Systematic Review and Network Meta-Analysis2023Cardiovascular Therapeutics
Comparative outcomes associated with rivaroxaban versus warfarin use in elderly patients with atrial fibrillation or acute venous thromboembolism managed in the United States: a systematic review of observational studies2023Current Medical Research And Opinion
DOACs in the Anticoagulation of Mechanical Valves: A Systematic Review and Future Perspectives2023Journal Of Clinical Medicine
Oral direct thrombin inhibitors or oral factor Xa inhibitors versus conventional anticoagulants for the treatment of deep vein thrombosis2023The Cochrane Database Of Systematic Reviews
Oral direct thrombin inhibitors or oral factor Xa inhibitors versus conventional anticoagulants for the treatment of pulmonary embolism2023The Cochrane Database Of Systematic Reviews
Direct Oral Anticoagulants Versus Warfarin Across the Spectrum of Kidney Function: Patient-Level Network Meta-Analyses From COMBINE AF2023Circulation
Prophylactic Efficacy and Safety of Antithrombotic Regimens in Patients with Stable Atherosclerotic Cardiovascular Disease (S-ASCVD): A Bayesian Network Meta-Regression Analysis2023American Journal Of Cardiovascular Drugs : Drugs, Devices, And Other
Application of rivaroxaban in patients with non-valvular atrial fibrillation and end-stage kidney disease: A systematic review and meta-analysis2023Frontiers In Cardiovascular Medicine
Transferability of Published Population Pharmacokinetic Models for Apixaban and Rivaroxaban to Subjects with Obesity Treated for Venous Thromboembolism: A Systematic Review and External Evaluations2023Pharmaceutics
Direct Oral Anticoagulants as the First Choice of Anticoagulation for Patients with Peripheral Artery Disease to Prevent Adverse Vascular Events: A Systematic Review and Meta-Analysis2023Journal Of Cardiovascular Development And Disease
Novel Oral Anticoagulants in Patients With Atrial Fibrillation and Moderate to Severe Mitral Stenosis: A Systematic Review2023Cureus
Anticoagulant Therapy for Cancer-Associated Thrombosis : A Cost-Effectiveness Analysis2023Annals Of Internal Medicine
Efficacy and safety outcomes of long-term anti-thrombotic treatment of chronic coronary artery disease: A systematic review and network meta-analysis2022Frontiers In Cardiovascular Medicine
Combination of antiplatelet and anticoagulant therapy, component network meta-analysis of randomized controlled trials2022Frontiers In Cardiovascular Medicine
Effect of direct oral anticoagulants in patients with atrial fibrillation with mitral or aortic stenosis: A review2022Frontiers In Cardiovascular Medicine
Efficacy and Safety of Direct Oral Anticoagulants in Patients With Antiphospholipid Syndrome: A Systematic Review and Meta-Analysis2022Cureus
Comparative efficacy and safety of antiplatelet or anticoagulant therapy in patients with chronic coronary syndromes after percutaneous coronary intervention: A network meta-analysis of randomized controlled trials2022Frontiers In Pharmacology
Anticoagulant for treatment and prophylaxis of venous thromboembolism patients with renal dysfunction: A systematic review and network meta-analysis2022Frontiers In Medicine
Major Hemorrhage Risk Associated with Direct Oral Anticoagulants in Non-Valvular Atrial Fibrillation: A Systematic Review and Meta-Analysis2022Reviews In Cardiovascular Medicine
Rivaroxaban Pharmacokinetics in Obese Subjects: A Systematic Review2022Clinical Pharmacokinetics
Efficacy and Safety of Direct Oral Anticoagulants in Stable Coronary Artery Disease and Atrial Fibrillation: A Systematic Review and Network Meta-Analysis2022Clinical And Applied Thrombosis/Hemostasis : Official Journal Of The
Efficacy of traditional Chinese medicine combined with rivaroxaban in the treatment of lower extremity deep vein thrombosis: A meta-analysis2022Medicine
Comparison of Aspirin and Rivaroxaban Plus Aspirin in the Management of Stable Coronary Artery Disease or Peripheral Artery Disease: A Systematic Review of Randomized Controlled Trials2022International Journal Of General Medicine
Comparative Efficacy of Rivaroxaban and Immunoglobulin Therapy in the Treatment of Livedoid Vasculopathy: A Systematic Review2022Cureus
Effects of oral anticoagulant therapy in patients with pulmonary diseases2022Frontiers In Cardiovascular Medicine
Cost-effectiveness of New Oral Anticoagulants for the Prevention of Stroke in Patients with Atrial Fibrillation in Low and Middle-Income Countries: A Systematic Review2022Medical Journal Of The Islamic Republic Of Iran
Antithrombotic Therapy for Symptomatic Peripheral Arterial Disease: A Systematic Review and Network Meta-Analysis2022Drugs
Interventions for preventing venous thromboembolism in adults undergoing knee arthroscopy2022The Cochrane Database Of Systematic Reviews
Comparison of the Efficacy and Safety of Rivaroxaban and Enoxaparin as Thromboprophylaxis Agents for Orthopedic Surgery-Systematic Review and Meta-Analysis2022Journal Of Clinical Medicine
Comparing the efficacy and safety of direct oral anticoagulants versus Vitamin K antagonists in patients with antiphospholipid syndrome: a systematic review and meta-analysis2022Blood Coagulation & Fibrinolysis : An International Journal In Haemostasis And
Effectiveness and safety of intracranial events associated with the use of direct oral anticoagulants for atrial fibrillation: A systematic review and meta-analysis of 92 studies2022British Journal Of Clinical Pharmacology
Prevention of venous thromboembolic events in patients with lower leg immobilization after trauma: Systematic review and network meta-analysis with meta-epsidemiological approach2022Plos Medicine
Effectiveness and Safety of Nonvitamin K Oral Anticoagulants Rivaroxaban and Apixaban in Patients with Venous Thromboembolism: A Meta-Analysis of Real-World Studies2022Cardiovascular Therapeutics
Comparative Risks of Fracture Among Direct Oral Anticoagulants and Warfarin: A Systematic Review and Network Meta-Analysis2022Frontiers In Cardiovascular Medicine
Thromboprophylaxis of Patients Submitted to Total Hip and Knee Arthroplasty: A Cost-Effectiveness Assessment From the Perspective of the Brazilian National Health System2022Value In Health Regional Issues
The use of non-vitamin K oral anticoagulants in dialysis patients-A systematic review2022Seminars In Dialysis
Direct oral anticoagulation in atrial fibrillation and heart valve surgery-a meta-analysis and systematic review2022Therapeutic Advances In Cardiovascular Disease
Oral anticoagulants and relative risk of acute kidney injury in patients with atrial fibrillation: A systematic review and network meta-analysis2022American Heart Journal Plus : Cardiology Research And Practice
Comparative Safety and Efficacy of Eight Antithrombotic Regimens for Patients With Atrial Fibrillation Undergoing Percutaneous Coronary Intervention2022Frontiers In Cardiovascular Medicine
Comparative efficacy and safety of oral anticoagulants for the treatment of venous thromboembolism in the patients with different renal functions: a systematic review, pairwise and network meta-analysis2022Bmj Open
Latest outcomes of transcatheter left atrial appendage closure devices and direct oral anticoagulant therapy in patients with atrial fibrillation over the past 5 years: a systematic review and meta-analysis2022Cardiovascular Intervention And Therapeutics
Efficacy and Safety of Enoxaparin versus New Oral Anticoagulants to Prevent Venous Thromboembolism after Total Hip Replacement: A Systematic Review and Meta-Analysis2022Journal Of Personalized Medicine
Antithrombotic therapy for secondary prevention of unprovoked venous thromboembolism: a systematic review and network meta-analysis of randomized controlled trials2022Annals Of Medicine
Editor's Choice - Severe Bleeding Risks of Direct Oral Anticoagulants in the Prevention and Treatment of Venous Thromboembolism: A Network Meta-Analysis of Randomised Controlled Trials2022European Journal Of Vascular And Endovascular Surgery : The Official Journal Of
Risk of Intracranial Hemorrhage Caused by Direct Oral Anticoagulants for Stroke Prevention in Patients With Atrial Fibrillation (from a Network Meta-Analysis of Randomized Controlled Trials)2022The American Journal Of Cardiology
Extended venous thromboprophylaxis in patients hospitalized for acute ischemic stroke: A systematic review and meta-analysis2022European Journal Of Internal Medicine
Combination anticoagulant or P2Y12 inhibitor with low-dose aspirin versus low-dose aspirin alone in patients at risk or with documented coronary and/or peripheral artery disease2022Current Medical Research And Opinion
Economic evaluation of direct oral anticoagulants (DOACs) versus vitamin K antagonists (VKAs) for stroke prevention in patients with atrial fibrillation: a systematic review and meta-analysis2022Bmj Evidence-Based Medicine
Wound complications and bleeding with new oral anticoagulants in patients undergoing total joint arthroplasty: A systematic review and meta-analysis of randomized controlled trials2022British Journal Of Clinical Pharmacology
Efficacy and safety of dual-pathway inhibition in patients with cardiovascular disease: a meta-analysis of 49 802 patients from 7 randomized trials2022European Heart Journal. Cardiovascular Pharmacotherapy
A network meta-analysis of direct factor Xa inhibitors for the treatment of cancer-associated venous thromboembolism2022Vascular
Risk of intracranial hemorrhage with direct oral anticoagulants: a systematic review and meta-analysis of randomized controlled trials2022Journal Of Neurology
Current Trends in the Duration of Anticoagulant Therapy for Venous Thromboembolism: A Systematic Review2021Cureus
Reappraisal of Non-vitamin K Antagonist Oral Anticoagulants in Atrial Fibrillation Patients: A Systematic Review and Meta-Analysis2021Frontiers In Cardiovascular Medicine
Effectiveness of Direct Oral Anticoagulants in Obese Adults With Atrial Fibrillation: A Systematic Review of Systematic Reviews and Meta-Analysis2021Frontiers In Cardiovascular Medicine
Oral anticoagulation in people with cancer who have no therapeutic or prophylactic indication for anticoagulation2021The Cochrane Database Of Systematic Reviews
Efficacy and Safety of Rivaroxaban Compared with Other Therapies Used in Patients with Peripheral Artery Disease Undergoing Peripheral Revascularization: A Systematic Literature Review and Network Meta-Analysis2021Cardiovascular Therapeutics
Safety and Efficacy of Apixaban, Rivaroxaban, and Warfarin in End-Stage Renal Disease With Atrial Fibrillation: A Systematic Review and Meta-Analysis2021Cardiovascular Revascularization Medicine : Including Molecular Interventions
Efficacy and safety of Xa inhibitors in patients with heart failure and coronary or peripheral artery disease: a systematic review and meta-analysis of randomized controlled trials2021Annals Of Palliative Medicine
Benefits and Harms of Low-Dose Rivaroxaban in Asian Patients With Atrial Fibrillation: A Systematic Review and Meta-analysis of Real-World Studies2021Frontiers In Pharmacology
A Systematic Review of the Efficacy and Safety of Direct Oral Anticoagulants in Atrial Fibrillation Patients with Diabetes Using a Risk Index2021Journal Of Clinical Medicine
Rivaroxaban for treatment of livedoid vasculopathy: A systematic review2021Dermatologic Therapy
Efficacy and safety of anticoagulants for postoperative thrombophylaxis in total hip and knee arthroplasty: A PRISMA-compliant Bayesian network meta-analysis2021Plos One
Antiplatelet therapy with or without anticoagulant therapy for lower extremity peripheral artery disease: A systematic review2021American Journal Of Health-System Pharmacy : Ajhp : Official Journal Of The
Efficacy and Safety of Rivaroxaban Therapy for Patients With Peripheral Artery Disease: A Systematic Review and Meta-Analysis2021Vascular And Endovascular Surgery
Efficacy and Safety of Direct Oral Anticoagulants in Venous Thromboembolism Compared to Traditional Anticoagulants in Morbidly Obese Patients: A Systematic Review and Meta-Analysis2021Cureus
Comparative effectiveness and safety of direct acting oral anticoagulants in nonvalvular atrial fibrillation for stroke prevention: a systematic review and meta-analysis2021European Journal Of Epidemiology
Efficacy and Safety of Non-Vitamin K Antagonist Oral Anticoagulants in Pediatric Venous Thromboembolism Treatment and Thromboprophylaxis: A Systematic Review of the Literature2021Seminars In Thrombosis And Hemostasis
Efficacy and safety of direct oral anticoagulants for treatment of left ventricular thrombus; a systematic review2021Acta Cardiologica
Efficacy of rivaroxaban in prevention of post-thrombotic syndrome: A systematic review and meta-analysis2021Journal Of Vascular Surgery. Venous And Lymphatic Disorders
Rivaroxaban for cancer-associated venous thromboembolism2021Science Progress
Progress in aorta and peripheral cardiovascular disease research2021Cardiovascular Research
Comparison of the Safety and Efficacy of Direct Oral Anticoagulants and Warfarin in Atrial Fibrillation or Venous Thromboembolism in Patients with Renal Impairment: Systematic Review, Meta-Analysis and Network Meta-Analysis2021American Journal Of Cardiovascular Drugs : Drugs, Devices, And Other
The risk of gastrointestinal hemorrhage with non-vitamin K antagonist oral anticoagulants: A network meta-analysis2021Medicine
The efficacy and safety of direct oral anticoagulants plus aspirin in symptomatic lower extremity peripheral arterial disease: a systematic review and meta-analysis of randomized controlled trials2021Journal Of Thrombosis And Thrombolysis
Reasons for discontinuing oral anticoagulation therapy for atrial fibrillation: a systematic review2021Age And Ageing
Efficacy and Safety of Long-Term Antithrombotic Strategies in Patients With Chronic Coronary Syndrome: A Network Meta-analysis of Randomized Controlled Trials2021Journal Of The American Heart Association
The Net Clinical Benefit of Rivaroxaban Compared to Low-Molecular-Weight Heparin in the Treatment of Cancer-Associated Thrombosis: Systematic Review and Meta-Analysis2021Clinical And Applied Thrombosis/Hemostasis : Official Journal Of The
Comparative Risk Assessment of Severe Uterine Bleeding Following Exposure to Direct Oral Anticoagulants: A Network Study Across Four Observational Databases in the USA2021Drug Safety
Direct oral anticoagulants in treatment of cerebral venous thrombosis: a systematic review2021Bmj Open
Cost-Effectiveness of Direct Non-Vitamin K Oral Anticoagulants Versus Vitamin K Antagonists for the Management of Patients with Non-Valvular Atrial Fibrillation Based on Available "Real-World" Evidence: The Italian National Health System Perspective2021Clinical Drug Investigation
Rivaroxaban versus aspirin in prevention of venous thromboembolism following total joint arthroplasty or hip fracture surgery: a meta-analysis2021Journal Of Orthopaedic Surgery And Research
Risk of Stroke vs. Intracerebral Hemorrhage in Patients with Non-Valvular Atrial Fibrillation Undergoing Percutaneous Coronary Intervention: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Comparing Dual vs. Triple Antithrombotic Therapy2021Journal Of Stroke And Cerebrovascular Diseases : The Official Journal Of National
Effect of Rivaroxaban or Apixaban in Atrial Fibrillation Patients with Stage 4-5 Chronic Kidney Disease or on Dialysis2021Cardiovascular Drugs And Therapy
Pharmacogenetics of Direct Oral Anticoagulants: A Systematic Review2021Journal Of Personalized Medicine
A network meta-analysis of non-vitamin K antagonist oral anticoagulants versus warfarin in patients with atrial fibrillation and diabetes mellitus2021Acta Cardiologica
Effectiveness and safety among direct oral anticoagulants in nonvalvular atrial fibrillation: A multi-database cohort study with meta-analysis2021British Journal Of Clinical Pharmacology
Benefit and risk of adding rivaroxaban in patients with coronary artery disease: A systematic review and meta-analysis2021Clinical Cardiology
Direct oral anticoagulants in antiphospholipid syndrome: Meta-analysis of randomized controlled trials2021Autoimmunity Reviews
Off-label Use for Direct Oral Anticoagulants: Valvular Atrial Fibrillation, Heart Failure, Left Ventricular Thrombus, Superficial Vein Thrombosis, Pulmonary Hypertension-a Systematic Review2021The Annals Of Pharmacotherapy
Direct Oral Anticoagulant Use in Chronic Kidney Disease and Dialysis Patients With Venous Thromboembolism: A Systematic Review of Thrombosis and Bleeding Outcomes2021The Annals Of Pharmacotherapy
Mortality benefit in the COMPASS trial: is it related to superior statistical power or better efficacy and safety?2021Future Cardiology
The Safety and Efficacy of Rivaroxaban Compared with Warfarin in Patients with Atrial Fibrillation and Diabetes: A Systematic Review and Meta-analysis2021American Journal Of Cardiovascular Drugs : Drugs, Devices, And Other
Efficacy and Safety of Tranexamic Acid Combined with Rivaroxaban in Primary Total Knee Arthroplasty: A Meta-Analysis of Randomized Controlled Trials2021Journal Of Investigative Surgery : The Official Journal Of The Academy Of
Low Dose Rivaroxaban for Atherosclerotic Cardiovascular Diseases: A Systematic Review and Meta-analysis2020Frontiers In Pharmacology
Dosage of Anticoagulants in Obesity: Recommendations Based on a Systematic Review2020Seminars In Thrombosis And Hemostasis
Primary prophylaxis for venous thromboembolism in ambulatory cancer patients receiving chemotherapy2020The Cochrane Database Of Systematic Reviews
Net Clinical Benefit of Direct Oral Anticoagulants in Patients With Cancer and Venous Thromboembolism: A Systematic Review and Trade-Off Analysis2020Frontiers In Cardiovascular Medicine
Efficacy and Safety of Oral Anticoagulants in Patients with Systolic Heart Failure in Sinus Rhythm: A Systematic Review and Meta-analysis of Randomized Controlled Trials and Cohort Studies2020Th Open : Companion Journal To Thrombosis And Haemostasis
Antiplatelet and anticoagulant agents for secondary prevention of stroke and other thromboembolic events in people with antiphospholipid syndrome2020The Cochrane Database Of Systematic Reviews
Assessing the benefits and harms of direct oral anticoagulants in patients with cancer for the prophylaxis and treatment of venous thromboembolism: a systematic review and meta-analysis2020Ecancermedicalscience
Safety and efficacy of dual versus triple antithrombotic therapy (DAT vs TAT) in patients with atrial fibrillation following a PCI: a systematic review and network meta-analysis2020Bmj Open
Risk of post-thrombotic syndrome after deep vein thrombosis treated with rivaroxaban versus vitamin-K antagonists: A systematic review and meta-analysis2020Thrombosis Research
Different Coagulation Indicators in Predicting Clinical Outcomes for Patients With Direct Oral Anticoagulants: A Systematic Review and Meta-analysis2020Clinical Therapeutics
Primary prophylaxis for venous thromboembolism in ambulatory cancer patients: a systematic review and network meta-analysis2020Annals Of Palliative Medicine
New Horizons in Pharmacologic Therapy for Secondary Stroke Prevention2020Jama Neurology
Antithrombotic Treatments in Patients with Chronic Coronary Artery Disease or Peripheral Artery Disease: A Systematic Review of Randomised Controlled Trials2020Cardiovascular Therapeutics
Bleeding Risk in Nonvalvular Atrial Fibrillation Patients Receiving Direct Oral Anticoagulants and Warfarin: A Systematic Review and Meta-Analysis of Observational Studies2020Th Open : Companion Journal To Thrombosis And Haemostasis
Oral factor Xa inhibitors and risk of subdural hematoma: COMPASS trial results and meta-analysis2020Neurology
Comparative Effects Between Direct Oral Anticoagulants for Acute Venous Thromboembolism: Indirect Comparison From Randomized Controlled Trials2020Frontiers In Medicine
The role of non-vitamin K antagonist oral anticoagulants in Asian patients with atrial fibrillation: A PRISMA-compliant article2020Medicine
Extended DOAC therapy in patients with VTE and potential risk of recurrence: A systematic review and meta-analysis2020Journal Of Thrombosis And Haemostasis : Jth
Direct oral anticoagulants versus vitamin K antagonists in antiphospholipid syndrome: A meta-analysis2020European Journal Of Internal Medicine
Efficacy and Safety of Non-Vitamin K Anticoagulants for Atrial Fibrillation in Relation to Different Renal Function Levels: A Network Meta-Analysis2020Cardiovascular Therapeutics
Meta-Analysis of Antithrombotic Strategies in Patients With Heart Failure With Reduced Ejection Fraction and Sinus Rhythm2020The American Journal Of Cardiology
Net clinical benefit of antithrombotic therapy in patients with heart failure and sinus rhythm: A network meta-analysis from 5 clinical trials2020Thrombosis Research
Efficacy and Safety of Direct Oral Anticoagulants in Elderly Patients With Atrial Fibrillation: A Network Meta-Analysis2020Frontiers In Medicine
Aspirin or anticoagulation after cryptogenic stroke with patent foramen ovale: systematic review and meta-analysis of randomized controlled trials2020Neurological Sciences : Official Journal Of The Italian Neurological Society And
Non-Vitamin K Antagonist Oral Anticoagulants in Secondary Stroke Prevention in Atrial Fibrillation Patients: An Updated Analysis by Adding Observational Studies2020Cardiovascular Drugs And Therapy
Efficacy and safety of low dose rivaroxaban in patients with coronary heart disease: a systematic review and meta-analysis2020Journal Of Thrombosis And Thrombolysis
Direct Oral Anticoagulants for the Treatment of Left Ventricular Thrombus-A New Indication? A Meta-summary of Case Reports2020Journal Of Cardiovascular Pharmacology
Real-World Adherence and Persistence to Direct Oral Anticoagulants in Patients With Atrial Fibrillation: A Systematic Review and Meta-Analysis2020Circulation. Cardiovascular Quality And Outcomes
Clinical Effectiveness and Safety of Aspirin for Venous Thromboembolism Prophylaxis After Total Hip and Knee Replacement: A Systematic Review and Meta-analysis of Randomized Clinical Trials2020Jama Internal Medicine
Direct oral anticoagulants for thromboprophylaxis in ambulatory patients with cancer2020Hematology (Amsterdam, Netherlands)
Real-world cost-effectiveness of rivaroxaban compared with vitamin K antagonists in the context of stroke prevention in atrial fibrillation in France2020Plos One
Oral Anticoagulation for Patients With Atrial Fibrillation on Long-Term Hemodialysis2020Journal Of The American College Of Cardiology
A systematic review on the effects of direct oral anticoagulants on cancer growth and metastasis in animal models2020Thrombosis Research
A Systematic Review of Network Meta-Analyses and Real-World Evidence Comparing Apixaban and Rivaroxaban in Nonvalvular Atrial Fibrillation2020Clinical And Applied Thrombosis/Hemostasis : Official Journal Of The
A comparison of aspirin against rivaroxaban for venous thromboembolism prophylaxis after hip or knee arthroplasty: A meta-analysis2020Journal Of Orthopaedic Surgery (Hong Kong)
Safety of Intravenous Thrombolysis Among Patients Taking Direct Oral Anticoagulants: A Systematic Review and Meta-Analysis2020Stroke
Use of Direct Oral Anticoagulants in Morbidly Obese Patients2020Pharmacotherapy
Revisiting the effects of omitting aspirin in combined antithrombotic therapies for atrial fibrillation and acute coronary syndromes or percutaneous coronary interventions: meta-analysis of pooled data from the PIONEER AF-PCI, RE-DUAL PCI, and AUGUSTUS trials2020Europace : European Pacing, Arrhythmias, And Cardiac Electrophysiology : Journal
Direct Anticoagulants and Risk of Myocardial Infarction, a Multiple Treatment Network Meta-Analysis2020Angiology
A comparison of anticoagulation, antiplatelet, and placebo treatment for patients with heart failure reduced ejection fraction in sinus rhythm: a systematic review and meta-analysis2020Heart Failure Reviews
Effectiveness and safety of direct oral anticoagulants in atrial fibrillation patients switched from vitamin K antagonists: A systematic review and meta-analysis2020Basic & Clinical Pharmacology & Toxicology
Risk of Major Gastrointestinal Bleeding With New vs Conventional Oral Anticoagulants: A Systematic Review and Meta-analysis2020Clinical Gastroenterology And Hepatology : The Official Clinical Practice Journal
Which patients with unprovoked venous thromboembolism should receive extended anticoagulation with direct oral anticoagulants? A systematic review, network meta-analysis, and decision analysis2020Journal Of Evaluation In Clinical Practice
Use of Direct Oral Anticoagulants in the Treatment of Left Ventricular Thrombus: Systematic Review of Current Literature2020American Journal Of Therapeutics
Non-vitamin K antagonist oral anticoagulants (NOACs) post-percutaneous coronary intervention: a network meta-analysis2019The Cochrane Database Of Systematic Reviews
Direct Oral Factor Xa Inhibitors for the Treatment of Acute Cancer-Associated Venous Thromboembolism: A Systematic Review and Network Meta-analysis2019Mayo Clinic Proceedings
Direct oral anticoagulant for the prevention of thrombosis in ambulatory patients with cancer: A systematic review and meta-analysis2019Journal Of Thrombosis And Haemostasis : Jth
Impact of methodological choices on a meta-analysis of real-world evidence comparing non-vitamin-K antagonist oral anticoagulants with vitamin K antagonists for the treatment of patients with non-valvular atrial fibrillation2019Current Medical Research And Opinion
Hemorrhagic Cardiac Tamponade Associated with Apixaban: A Case Report and Systematic Review of Literature2019Cardiovascular Revascularization Medicine : Including Molecular Interventions

Clinical Practice Guidelines

Document TitleYearSource
Venous Thromboembolism Prophylaxis and Treatment in Patients With Cancer: ASCO Guideline Update.2023Journal of Clinical Oncology
Direct Oral Anticoagulant (DOAC) Guidelines.2023New South Wales Government – Clinical Excellence Commission
2023 ACC/AHA/ACCP/HRS Guideline for the Diagnosis and Management of Atrial Fibrillation: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.2023Journal of the American College of Cardiology
American College of Gastroenterology-Canadian Association of Gastroenterology clinical practice guideline: Management of anticoagulants and antiplatelets during acute gastrointestinal bleeding and the periendoscopic period.2022Journal of the Canadian Association of Gastroenterology
2022 international clinical practice guidelines for the treatment and prophylaxis of venous thromboembolism in patients with cancer, including patients with COVID-19.2022The Lancet: Oncology
Canadian cardiovascular society 2022 guidelines for peripheral arterial disease.2022Canadian Journal of Cardiology
Perioperative Management of Antithrombotic Therapy: An American College of Chest Physicians Clinical Practice Guideline.2022Chest
2021 ESC guidelines on cardiovascular disease prevention in clinical practice.2021European Heart Journal
2019 ESC guidelines for the diagnosis and management of chronic coronary syndromes.2020European Heart Journal
Venous thromboembolic diseases: diagnosis, management and thrombophilia testing.2020NICE
Venous thromboembolism prophylaxis and treatment in patients with cancer: ASCO clinical practice guideline update.2020Journal of Clinical Oncology
2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS).2020European Heart Journal
The 2020 Canadian cardiovascular society/Canadian heart rhythm society comprehensive guidelines for the management of atrial fibrillation.2020Canadian Journal of Cardiology
American Society of Hematology 2020 guidelines for management of venous thromboembolism: Treatment of deep vein thrombosis and pulmonary embolism.2020Blood Advances
2019 ESC guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS).2020European Heart Journal
Reversal of direct oral anticoagulants: Guidance from the Anticoagulation Forum2019American Journal of Hematology
2019 AHA/ACC/HRS focused update of the 2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation.2019Circulation