Latanoprostene bunod ophthalmic solution



Drug updated on 5/17/2024

Dosage Formsolution (topical ophthalmic; 0.24 mg/mL [0.024%])
Drug ClassProstaglandin analogs
Ongoing and
Completed Studies


  • Indicated for the reduction of intraocular pressure in patients with open-angle glaucoma or ocular hypertension.

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  • Latanoprostene bunod ophthalmic solution (Vyzulta) is indicated for the reduction of intraocular pressure in patients with open-angle glaucoma or ocular hypertension. It demonstrates substantial efficacy compared to most beta-blockers and several prostaglandin analogues, specifically outperforming unoprostone.
  • The information was derived from a single systematic review/meta-analysis study that focused on comparing Vyzulta's effectiveness against other drugs used for reducing intraocular pressure.
  • Compared to Unoprostone, latanoprostene bunod was significantly more effective in reducing intraocular pressure with a mean difference in IOP reduction of -3.45 (-4.77 to -2.12).
  • When compared to other Prostaglandin Analogues (PGAs), it showed similar effectiveness as bimatoprost 0.01%, slightly less effective than bimatoprost 0.03% but more effective than latanoprost and tafluprost; however, this superiority wasn't statistically significant.
  • Against beta-blockers such as apraclonidine, betaxolol, brimonidine, brinzolamide, carteolol, dorzolamide, and timolol, latanoprostene bunod proved significantly superior at reducing IOP levels.
  • In terms of safety outcomes, the study did not provide explicit details hence comparisons between Vyzulta and other medications based on this study cannot be provided. However, it should be noted that individual safety profiles and tolerance therapy are important considerations when choosing these medications for the management of open-angle glaucoma or ocular hypertension.

Product Monograph / Prescribing Information

Document TitleYearSource
Vyzulta (latanoprostene bunod ophthalmic solution) Prescribing Information.2019Bausch Health US, LLC., Bridgewater, NJ

Systematic Reviews / Meta-Analyses

Clinical Practice Guidelines

Document TitleYearSource
Primary open-angle glaucoma preferred practice pattern.2021Ophthalmology