Drug updated on 9/4/2024
Dosage Form | Capsule (oral; 10 mg, 20 mg, 30 mg, 40 mg, 50 mg, 60 mg, 70 mg); Chewable tablet (oral; 10 mg, 20 mg, 30 mg, 40 mg, 50 mg, 60 mg) |
Drug Class | Central nervous system stimulants |
Ongoing and Completed Studies | ClinicalTrials.gov |
Indication
- Indicated for the treatment of Attention Deficit Hyperactivity Disorder (ADHD) in adults and pediatric patients 6 years and older.
- Indicated for the treatment of moderate to severe binge eating disorder (BED) in adults.
Latest News
Summary
- Vyvanse (lisdexamfetamine dimesylate) is indicated for the treatment of Attention Deficit Hyperactivity Disorder (ADHD) in adults and pediatric patients 6 years and older, as well as for the treatment of moderate to severe binge eating disorder (BED) in adults.
- This summary is based on the review of three systematic review(s)/meta-analysis(es). [1-3]
- Lisdexamfetamine (LDX) is effective in treating Binge-Eating Disorder (BED), consistently reducing BED symptoms and body weight in patients.
- In adults with Attention-Deficit Hyperactivity Disorder (ADHD), LDX demonstrated the highest effect size in reducing ADHD symptoms (SMD = -0.89) compared to mixed amphetamine salts (SMD = -0.64) and methylphenidate (SMD = -0.50), indicating superior efficacy among psychostimulants.
- No significant differences in serious adverse events were found between ADHD pharmacotherapies (including LDX) and placebo, although a higher proportion of participants withdrew due to adverse events in the pharmacotherapy group.
- There were no specific safety outcomes or adverse effects detailed for LDX in the treatment of Binge-Eating Disorder (BED).
- Few randomized controlled trials (RCTs) reported on long-term adverse events.
- There is no population types or subgroups information available in the reviewed studies.
Product Monograph / Prescribing Information
Document Title | Year | Source |
---|---|---|
Vyvanse (lisdexamfetamine dimesylate) Prescribing Information. | 2023 | Takeda Pharmaceuticals America, Inc., Lexington |