Summary

This AI-generated content is provided without warranty, with no liability accepted for reliance on it. Learn more.

• Sofosbuvir, velpatasvir, and voxilaprevir (Vosevi) is recommended for the management of chronic HCV infection in adult patients without cirrhosis or with compensated cirrhosis who have genotype 1, 2, 3, 4, 5, or 6 infection and have previously received an HCV regimen containing an NS5A inhibitor. It is also effective in managing adults with genotype 1a or 3 infections previously treated using a sofosbuvir-based regimen without an NS5A inhibitor.
• Four systematic reviews/meta-analyses provided insights into its efficacy as a salvage treatment for Chronic Hepatitis C patients who had previous treatments fail.
• The medication has demonstrated high effectiveness as a rescue therapy among Chronic Hepatitis C patients whose prior direct-acting antiviral treatments failed. Predictors of treatment failure include active hepatocellular carcinoma (HCC), baseline cirrhosis, and prior exposure to SOF/VEL combination drugs.
• Regarding the safety profile across different population types, including diabetic patients managing HCV treatment failure, rare instances of grade three hyperglycemia necessitate careful monitoring during administration among this subgroup.
• Real-world effectiveness studies indicate SVR12 rates between 93%-96% among HCV-infected individuals experiencing previous therapeutic failures. Adverse events are generally mild, but serious adverse events occur at a rate of approximately four percent.
• In comparison to other regimens like GLE+PIB specifically for GT3 infected individuals post-treatment failure, while Vosevi remains an effective option with a lower SVR rate at around eighty-five percent, GLE+PIB shows higher success rates nearing ninety-nine percent, indicating potential superiority in such cases.