Summary

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• Aprocitentan (Tryvio) is indicated for the treatment of hypertension in combination with other antihypertensive drugs, specifically targeting adult patients who are not adequately controlled on existing medications. This drug lowers blood pressure and reduces the risk of fatal and non-fatal cardiovascular events such as strokes and myocardial infarctions.
• Two systematic review/meta-analysis studies were reviewed to gather information about this drug's role in managing resistant hypertension compared to other therapies.
• The first study discusses resistant hypertension (RHT), a condition that does not respond well to conventional triple combination therapy. Patients with RHT have a high-risk profile due to their susceptibility to organ damage mediated by hypertension and cardiovascular events.
• According to the second study, Aprocitentan has shown promise as an effective antihypertensive option for patients suffering from resistant forms of hypertension. It significantly reduces both systolic and diastolic blood pressure at dosages of 10 mg and 25 mg.
• Compared with standard therapies, Aprocitentan offers a unique mechanism that directly antagonizes endothelin pathways, which differentiates it from other treatments. However, further research is needed regarding its long-term outcomes, efficacy, and safety profile when used alongside other antihypertensive drugs.
• Both studies focus particularly on adults with resistant hypertension—a subgroup notoriously difficult to treat effectively—suggesting that Aprocitentan could fill significant gaps in current management regimens for these individuals.