Drug updated on 5/17/2024
Dosage Form | Injection (intravenous; 40 mg) |
Drug Class | Tissue factor-directed antibodies and microtubule inhibitors |
Ongoing and Completed Studies | ClinicalTrials.gov |
Indication
- Indicated for the treatment of adult patients with recurrent or metastatic cervical cancer with disease progression on or after chemotherapy.
Latest News
![loading GIF](/img/news-loading.gif)
Summary
- Tisotumab vedotin-tftv (Tivdak) is used for treating adult patients with recurrent or metastatic cervical cancer that has progressed on or after chemotherapy, targeting tissue factor which is highly expressed in this type of carcinoma.
- Two studies from Randomized Controlled Trials were reviewed to gather information about the safety and effectiveness of Tivdak.
- The first study presents a combination of Tivdak with bevacizumab, pembrolizumab, or carboplatin in diverse settings for recurrent/metastatic cervical cancer. Objective Response Rate varied across treatment combinations and lines of therapy: 54.5% (1L TV + carboplatin), 40.6% (1L TV + pembrolizumab), and 35.3% (2L/3L TV + pembrolizumab).
- Adverse events such as anemia, diarrhea, nausea, and thrombocytopenia were reported but are manageable according to the same study.
- The second study focuses on single-agent efficacy of Tivdak in patients who progressed on previous treatments including doublet chemotherapy with bevacizumab if eligible; it showed an ORR of 24%, indicating considerable antitumor activity.
- Both studies enrolled adult patients with recurrent or metastatic cervical cancer, providing insights into its use across different patient subgroups and suggesting a flexible application of tisotumab vedotin-tftv in clinical management due to its favorable balance between efficacy and safety compared to existing treatments.
Product Monograph / Prescribing Information
Document Title | Year | Source |
---|---|---|
Tivdak (tisotumab vedotin-tftv) Prescribing Information. | 2023 | Seagen Inc., Bothell, WA |
Randomized Controlled Trials
Document Title | Sex Distribution | Year | Source |
---|---|---|---|
Tisotumab vedotin in Japanese patients with recurrent/metastatic cervical cancer: Results from the innovaTV 206 study. | 142Subjects F: 100% M: 0% | 2022 | Cancer Science |
Efficacy and safety of tisotumab vedotin in previously treated recurrent or metastatic cervical cancer (innovaTV 204/GOG-3023/ENGOT-cx6): a multicentre, open-label, single-arm, phase 2 study. | 101Subjects F: 100% M: 0% | 2021 | The Lancet Oncology |
Tisotumab vedotin in previously treated recurrent or metastatic cervical cancer. | 55Subjects F: 100% M: 0% | 2020 | Clinical Cancer Research |
Document Title
Sex Distribution:
F:100%
M:0%
142Subjects
Year:
2022
Source:Cancer Science
Sex Distribution:
F:100%
M:0%
101Subjects
Year:
2021
Source:The Lancet Oncology
Sex Distribution:
F:100%
M:0%
55Subjects
Year:
2020
Source:Clinical Cancer Research