Summary

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• This summary is based on the review of one randomized controlled trial. ^[1]
• Tisotumab vedotin showed a median overall survival (OS) of 11.5 months (95% confidence interval (CI), 9.8 to 14.9) compared to 9.5 months (95% CI, 7.9 to 10.7) with chemotherapy, with a 30% lower risk of death (hazard ratio (HR) 0.70; 95% CI, 0.54 to 0.89; P = 0.004).
• Progression-free survival (PFS) was significantly longer with tisotumab vedotin at 4.2 months (95% CI, 4.0 to 4.4) compared to 2.9 months (95% CI, 2.6 to 3.1) for chemotherapy (HR 0.67; 95% CI, 0.54 to 0.82; P < 0.001).
• The objective response rate (ORR) for tisotumab vedotin was 17.8%, significantly higher than the 5.2% seen with chemotherapy (odds ratio (OR) 4.0; 95% CI, 2.1 to 7.6; P < 0.001).
• Tisotumab vedotin was associated with an overall adverse event (AE) incidence of 98.4%, with 52.0% of patients experiencing grade 3 or greater AEs, compared to chemotherapy, which had a 99.2% incidence of AEs and 62.3% for grade 3 or greater AEs.
• Treatment discontinuation due to toxic effects occurred in 14.8% of patients treated with tisotumab vedotin.
• The study population consisted of patients with recurrent or metastatic cervical cancer who were receiving second- or third-line therapy. No specific subgroup analyses were reported, and the treatment groups for tisotumab vedotin and chemotherapy were similar in terms of demographic and disease characteristics.