Summary

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• Tepotinib (Tepmetko) is indicated for the treatment of adult patients with metastatic non-small cell lung cancer (NSCLC) harboring mesenchymal-epithelial transition (MET) exon 14 skipping alterations.
• Four systematic reviews/meta-analyses studies were reviewed to gather information about this drug. These studies provided insights into its effectiveness, safety profile, and considerations for specific populations or subgroups.
• Compared to other MET tyrosine kinase inhibitors such as savolitinib and capmatinib, Tepotinib showed higher objective response rates in trials involving NSCLC patients with METex14 skipping alterations. This suggests that it may be more effective in treating this particular subgroup of NSCLC patients.
• The safety profile of Tepotinib was found satisfactory among the options available for treating MET dysregulated NSCLC. Significant adverse events reported include lower extremity edema, alanine aminotransferase elevation, and lipase elevation; however, these are manageable, indicating an overall tolerable safety profile.
• Subgroup analysis revealed that elderly patients and those with adenocarcinoma histology who have METex14 skipping NSCLC could significantly benefit from Tepotinib compared to traditional treatments.
• In comparison to other drugs like savolitinib and capmatinib used in similar indications, Tepotinib offers competitive disease control rates while maintaining a consistent safety profile, making it a strong candidate within the treatment landscape for specific types of non-small cell lung cancer subtypes.