Summary

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• Seysara (sarecycline) is indicated for the treatment of inflammatory lesions of non-nodular moderate to severe acne vulgaris in patients ≥ 9 years of age.
• This summary is based on the review of one systematic review/meta-analysis. ^[1]
• Sarecycline demonstrated effectiveness in treating both facial and truncal acne in a population of pediatric and adult acne patients (total n=226,019).
• Other tetracyclines (doxycycline, minocycline, tetracycline) were noted as effective for facial acne, with no specific data provided on their effectiveness for truncal acne.
• The study highlights that Sarecycline may have a broader range of effectiveness compared to the other tetracyclines, covering both facial and truncal acne.
• The safety outcomes highlighted differences in the ability of oral tetracyclines to minimize antibiotic resistance and gut dysbiosis, though specific numerical data are not provided.
• The study suggests that sarecycline, as a narrow-spectrum tetracycline, may have a different safety profile concerning antibiotic resistance and gut dysbiosis compared to other tetracyclines, but no specific comparative safety data or details on adverse effects are reported.
• The systematic review included both pediatric and adult acne patients (totaling 226,019 individuals); however, there were no specific subgroup considerations or relevant findings pertinent to distinct population types or subgroups mentioned in the study.