Summary

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• Octreotide acetate (Sandostatin LAR Depot) is used for the treatment of acromegaly, severe diarrhea/flushing episodes associated with metastatic carcinoid tumors, and profuse watery diarrhea associated with Vasoactive Intestinal Peptide (VIP) secreting tumors.
• Three systematic reviews/meta-analyses were reviewed that discussed the use and effectiveness of octreotide acetate in various clinical scenarios.
• One review evaluated the efficiency of octreotide in stopping post-surgical Chyle Leak in neck dissection patients, finding it to be an effective way to manage this complication when combined with primary treatment.
• Another study examined its role when combined with other therapies such as everolimus or Peptide Receptor Radionuclide Therapy for neuroendocrine neoplasia management; disease control was observed in 85% cases while progression free survival ranged from 15 to 16.4 months and overall survival from 25 to 61.9 months.
• The third study compared octreotide's effectiveness against oral dietary modification (ODM) for managing chylous fistulae following neck surgery; no significant difference was found between both methods regarding time taken until resolution or rate of spontaneous resolution without need for surgery.
• Across all studies reviewed, Sandostatin LAR Depot showed a good safety profile being well-tolerated by patients experiencing few mild side effects not requiring drug withdrawal; however more robust randomized controlled trials are needed to confirm these findings across different patient populations and indications.