Elapegademase-lvlr

(Revcovi®)

Revcovi®

Drug updated on 5/17/2024

Dosage FormInjection (intramuscular; 2.4 mg/1.5 mL [1.6 mg/mL])
Drug ClassRecombinant adenosine deaminases
Ongoing and
Completed Studies
ClinicalTrials.gov

Indication

  • Indicated for the treatment of adenosine deaminase severe combined immunity deficiency (ADA-SCID) in pediatric and adult patients.

Summary
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  • Elapegademase-lvlr (Revcovi) is indicated for the treatment of adenosine deaminase severe combined immunodeficiency (ADA-SCID) in pediatric and adult patients. It has been compared to pegademase, a previously used enzyme replacement therapy.
  • The information originates from one study classified as a Randomized Controlled Trial.
  • In terms of safety, no adverse events were directly linked to Revcovi during the study. Compared to pegademase, Revcovi did not demonstrate drug-related adverse effects, suggesting it may have a favorable safety profile.
  • Regarding effectiveness, all patients achieved undetectable levels of deoxyadenosine nucleotide and sufficient enzyme activity as measured by trough serum ADA activity. This indicates that Revcovi successfully reproduced desired therapeutic effects comparable with those observed with pegademase use.
  • The study involved participants ranging from 0 to 25 years old, indicating its applicability across different age groups suffering from ADA SCID. However, an infant patient died due to pneumonia caused by cytomegalovirus infection, highlighting the need for close monitoring in vulnerable populations such as infants who have compromised immune systems due to their condition.
  • Despite these promising results regarding both safety and efficacy profiles of elapegademase-lvlr (Revcovi), further research involving larger sample sizes is needed, given this information was derived solely from one single-arm open-label study involving only four patients.

Product Monograph / Prescribing Information

Document TitleYearSource
Revcovi (elapegademase-lvlr) Prescribing Information.2020Chiesi USA, Inc. Cary, NC

Randomized Controlled Trials