Tacrolimus

(Prograf®)

Prograf®

Drug updated on 10/23/2023

Dosage FormCapsule (oral: 0.5 mg, 1 mg, 5 mg) Injection (intravenous: 5mg/mL) Granule (oral: 0.2 mg (1 mg))
Drug ClassCalcineurin-inhibitor immunosuppressant
Ongoing and
Completed Studies
ClinicalTrials.gov

Indication

  • For the prophylaxis of organ rejection in adult and pediatric patients receiving allogeneic liver, kidney, heart, or lung transplants, in combination with other immunosuppressants.

Product Monograph / Prescribing Information

Document TitleYearSource
Prograf (tacrolimus) Prescribing Information.2022Astellas Pharma US, Inc. Northbrook, IL

Systematic Reviews / Meta-Analyses

Document TitleYearSource
Efficacy and safety of tacrolimus combined with corticosteroids in patients with idiopathic membranous nephropathy: a systematic review and meta-analysis of randomized controlled trials.2022International Urology Nephrology
Efficacy and safety of tacrolimus monotherapy versus cyclophosphamide–corticosteroid combination therapy for idiopathic membranous nephropathy: a meta-analysis.2021Medicine
Efficacy and safety of tacrolimus monotherapy versus tacrolimus-corticosteroid combination therapy for idiopathic membranous nephropathy; a meta-analysis.2021Medicine
Tacrolimus versus cyclophosphamide for patients with idiopathic membranous nephropathy and treated with steroids: a systematic review and meta-analysis of randomized controlled trials.2021Renal Failure
Efficacy and safety of tacrolimus in patients with rheumatoid arthritis – a systematic review and meta-analysis.2021Modern Rheumatology
Population pharmacokinetic models of tacrolimus in adult transplant recipients: a systematic review.2020Clinical Pharmacokinetics
Effect of CYP3A5*1 expression on tacrolimus required dose for transplant pediatrics: a systematic review and meta-analysis.2018Pediatric Transplantation
Effect of CYP3A5*1 expression on tacrolimus required dose after liver transplantation: a systematic review and meta-analysis.2018Clinical Transplantation
Efficacy and safety of tacrolimus combined with glucocorticoid treatment for IgA nephropathy: a meta-analysis.2018Journal of International Medical Research

Clinical Practice Guidelines

Document TitleYearSource
English version of clinical practice guidelines for the management of atopic dermatitis 2021.2022Japanese Dermatological Association: The Journal of Dermatology
Clinical practice guidelines for the management of atopic dermatitis 2018.2019Japanese Dermatological Association: The Journal of Dermatology
Consensus-based European guidelines for treatment of atopic eczema (atopic dermatitis) in adults and children: part I.2018Journal of the European Academy of dermatology & Venerology