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Peginterferon beta-1a

(Plegridy®)

Plegridy®

Drug updated on 11/1/2024

Dosage FormInjection (subcutaneous: 125 mg/0.5 mL, 63 mg/0.5 mL, 94 mg/0.5 mL; Intramuscular: 125 mcg/0.5 mL)
Drug ClassInterferon beta
Ongoing and
Completed Studies		ClinicalTrials.gov

Indication

  • Indicated for the treatment of relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease, in adults.

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Summary
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  • This summary is based on the review of three systematic review(s)/meta-analysis(es). [1-3]
  • Peginterferon beta-1a (Plegridy) showed a significant reduction in relapse rates over 24 months in patients with relapsing-remitting multiple sclerosis (RRMS) compared to placebo (RR (relative risk) 0.63; 95% CI (confidence interval), 0.52 to 0.77) and demonstrated better effectiveness than Teriflunomide (RR 0.78) and IFN beta-1a (Avonex) (RR 0.87). However, it was less effective than Alemtuzumab and Ocrelizumab (both with RR 0.49), and Natalizumab and Fingolimod.
  • Peginterferon beta-1a did not significantly increase the rate of serious adverse events (SAEs) compared to placebo, with a risk ratio (RR) of 1.07 (95% CI 0.66 to 1.74), based on very low-certainty evidence.
  • The rate of treatment discontinuation due to adverse events was notably higher for Peginterferon beta-1a, with a risk ratio of 3.46 (95% CI 1.44 to 8.33) and an odds ratio of 1.48 (95% CI 0.99 to 2.20), indicating a significant increase in withdrawal compared to placebo.
  • There is no population types or subgroups information available in the reviewed studies.