Plavix

(Clopidogrel)

Plavix

Drug updated on 11/13/2023

Dosage FormTablet (oral: 75 mg, 300 mg)
Drug ClassPlatelet inhibitor
Ongoing and Completed StudiesClinicalTrials.gov

Indication

  • For acute coronary syndrome: for patients with non–ST-segment elevation ACS (unstable angina [UA]/non–ST-elevation myocardial infarction [NSTEMI]), Plavix has been shown to reduce the rate of myocardial infarction (MI) and stroke.
  • For acute coronary syndrome: for patients with ST-elevation myocardial infarction (STEMI), Plavix has been shown to reduce the rate of MI and stroke.
  • For recent MI, recent stroke, or established peripheral arterial disease. Plavix has been shown to reduce the rate of MI and stroke.

Product Monograph / Prescribing Information

Document TitleYearSource
Plavix (clopidogrel) Prescribing Information.2022Sanofi-aventis U.S. LLC Bridgewater, NJ

Systematic Reviews / Meta-Analyses

Document TitleYearSource
Clopidogrel vs aspirin monotherapy following dual antiplatelet therapy after percutaneous coronary intervention: a systematic review and meta-analysis.2023Current Problems in Cardiology
Assessment report; clopidogrel.2022EMA
Efficacy of ticagrelor compared to clopidogrel in improving endothelial function in patients with coronary artery disease: a systematic review.2022Journal of Cardiovascular Medicine
Comparison of ticagrelor with clopidogrel in east Asian patients with acute coronary syndrome: a systematic review and meta-analysis of randomized clinical trials.2022Journal of Cardiovascular Pharmacology
Potent P2Y12 inhibitors versus clopidogrel in elderly patients with acute coronary syndrome: systematic review and meta-analysis.2021American Heart Journal
Assessment report; clopidogrel.2020EMA
Risk factors for bleeding and clinical ineffectiveness associated with clopidogrel therapy: a comprehensive meta-analysis.2020Clinical and Translational Science
Antithrombotic therapy with or without clopidogrel after transcatheter aortic valve replacement. A meta-analysis of randomized controlled trials.2020Clinical Research in Cardiology
Long-term effect of clopidogrel in patients with and without diabetes: a systematic review and meta-analysis of randomized controlled trials.2020World Journal of Diabetes
Effects of the ABCB1 C3435T single nucleotide polymorphism on major adverse cardiovascular events in acute coronary syndrome or coronary artery disease patients undergoing percutaneous coronary intervention and treated with clopidogrel: a systematic review and meta-analysis.2020Expert Opinion on Drug Safety
Comparison of prasugrel and clopidogrel used as antiplatelet medication for endovascular treatment of unruptured intracranial aneurysms: a meta-analysis.2019American Journal of Neuroradiology
The effect of CYP2C19 and nongenetic factors on clopidogrel responsiveness in the mena region: a systematic review.2019Clinical and Applied Thrombosis/Hemostasis
Optimal duration of aspirin plus clopidogrel after ischemic stroke or transient ischemic attack.2019Stroke: American Heart Association
Association between P2RY12 gene polymorphisms and adverse clinical events in coronary artery disease patients treated with clopidogrel: a systematic review and meta-analysis.2018Gene

Clinical Practice Guidelines