Drug updated on 5/17/2024

Dosage FormSolution (oral; 10 g/packet, 280 g/bottle, 560 g/bottle)
Drug ClassOsmotic laxatives
Ongoing and
Completed Studies


  • Indicated for the treatment of chronic idiopathic constipation (CIC) in adults.

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  • Lactitol (Pizensy) is indicated for the treatment of chronic idiopathic constipation (CIC) in adults, especially within the elderly population.
  • The efficacy and safety of laxatives in treating constipation among patients over 65 years old were evaluated in one systematic review/meta-analysis.
  • This evaluation included 23 randomized controlled trials comparing various types of laxatives to placebos or other similar drugs.
  • In terms of efficacy, lactitol, along with several other laxatives, showed greater effectiveness than placebos for short-term use in elderly patients suffering from constipation. However, long-term safety and efficacy data specifically for lactitol were not provided, except for Polyethylene Glycol, which was highlighted as safe and effective for around six months of usage.
  • Regarding safety considerations, adverse effects reported did not differ significantly between treatment groups, suggesting a similar frequency and severity across different laxative treatments, including Pizensy (Lactitol).
  • It is important to note that these findings are based strictly on the studied material; additional comprehensive data could further refine these conclusions, especially concerning direct comparisons between Lactitol (Pizensy) and other laxatives, particularly regarding long-term use within specific subpopulations such as older adults.

Product Monograph / Prescribing Information

Document TitleYearSource
Pizensy (lactitol) Prescribing Information.2021Braintree Laboratories, Inc., Braintree, MA

Systematic Reviews / Meta-Analyses

Document TitleYearSource
Medical management of constipation in elderly patients: systematic review.2021Journal of Neurogastroenterology

Clinical Practice Guidelines