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Amlodipine besylate

(Norvasc®)

Norvasc®

Drug updated on 12/11/2024

Dosage FormTablet (oral: 2.5 mg, 5 mg, 10 mg)
Drug ClassCalcium channel blockers
Ongoing and
Completed Studies		ClinicalTrials.gov

Indication

  • For the treatment of hypertension, to lower blood pressure
  • Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions
  • For the treatment of coronary artery disease; chronic stable angina; vasospastic angina (prinzmetal's or variant angina); angiographically documented coronary artery disease in patients without heart failure or an ejection fraction < 40%.

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Summary
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  • This summary is based on the review of 11 systematic review(s)/meta-analysis(es). [1-11]
  • Perindopril/amlodipine fixed-dose combination significantly lowers blood pressure and improves blood pressure control, demonstrating superior adherence and fewer side effects compared to monotherapy and placebo in general hypertensive patients.
  • For vasospastic angina (VSA), diltiazem, nifedipine, and amlodipine effectively reduce VSA episodes; however, each presents different side effects, with diltiazem associated with atrioventricular block and nifedipine with excessive blood pressure reduction and heart rate increase.
  • In preventing atrial fibrillation (AF) recurrence in hypertensive patients, angiotensin II receptor blockers (ARBs) show superior effectiveness over calcium channel blockers (CCBs), including amlodipine.
  • In hypertensive patients with chronic kidney disease, benidipine outperforms amlodipine in improving estimated glomerular filtration rate (eGFR) and reducing urinary albumin/creatinine ratio, despite similar outcomes in blood pressure and heart rate reduction.
  • There is no population types or subgroups information available in the reviewed studies.

Product Monograph / Prescribing Information

Document TitleYearSource
Norvasc (amlodipine besylate) Prescribing Information.2023Viatris Specialty LLC, Canonsburg, PA

Systematic Reviews / Meta-Analyses

Document TitleYearSource
Single-Pill Combination Therapy of Amlodipine, Telmisartan, and Chlorthalidone in the Management of Hypertension: A Systematic Review of Randomized Controlled Trials2024Cureus
Effectiveness of perindopril/amlodipine fixed-dose combination in the treatment of hypertension: a systematic review2023Frontiers In Pharmacology
Efficacy and Safety of Azelnidipine as an Antihypertensive Compared to Amlodipine: A Systematic Review and Meta-analysis2023High Blood Pressure & Cardiovascular Prevention : The Official Journal Of The
Comparison of various calcium antagonist on vasospastic angina: a systematic review2023Open Heart
A Reappraisal of the Effects of L-type Ca(2+) Channel Blockers on Store-Operated Ca(2+) Entry and Heart Failure2023Function (Oxford, England)
Angiotensin Receptor Blocker and Calcium Channel Blocker Preventing Atrial Fibrillation Recurrence in Patients with Hypertension and Atrial Fibrillation: A Meta-analysis2021Cardiovascular Therapeutics
Berberine for the treatment of hypertension: A systematic review2021Complementary Therapies In Clinical Practice
Amlodipine Compared with Benidipine in the Management of Hypertension: A Systematic Review and Meta-Analysis2020High Blood Pressure & Cardiovascular Prevention : The Official Journal Of The
Comparative efficacy and safety of oral antihypertensive agents in pregnant women with chronic hypertension: a network metaanalysis2020American Journal Of Obstetrics And Gynecology
Economic evaluation of olmesartan/amlodipine fixed-dose combination for hypertension treatment in China2020Journal Of Medical Economics
Systematic Review with Network Meta-Analysis: Comparative Efficacy and Safety of Combination Therapy with Angiotensin II Receptor Blockers and Amlodipine in Asian Hypertensive Patients2019International Journal Of Hypertension

Clinical Practice Guidelines

Document TitleYearSource
Amlodipine in the current management of hypertension.2023The Journal of Clinical Hypertension
2019 ESC guidelines for the diagnosis and management of chronic coronary syndromes: the task force for the diagnosis and management of chronic coronary syndromes of the European Society of Cardiology (ESC).2020European Heart Journal