Summary

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• Nexplanon (etonogestrel) is indicated for use by women to prevent pregnancy.
• This summary is based on the review of four systematic review(s)/meta-analysis(es). ^[1-4]
• The ENG implant is highly effective as a contraceptive method, with some studies reporting 100% effectiveness and a Pearl Index ranging from 0 to 1.4 in women of reproductive age.
• Compared to other contraceptive methods, the ENG implant has lower one-year continuation rates, with odds ratios of 1.55 and 1.34 when compared to LNG-IUS and Cu-IUD, respectively.
• In women undergoing medical abortion with mifepristone, simultaneous administration of the ENG implant is associated with lower unintended pregnancy rates and higher patient satisfaction compared to delayed administration.
• No complications were observed during insertion, and no side effects were reported during follow-up in young women with chronic psychiatric disorders.
• The ENG implant is generally safe but is associated with abnormal menstrual bleeding, which commonly leads to premature discontinuation in the general population, including young girls post-partum/post-abortion.
• Abnormal menstruation was the most commonly reported side effect, with no significant changes in bone mineral density at one-year follow-up in women of reproductive age.
• ENG implant is effective and safe across diverse populations, including young women with psychiatric disorders, women post-partum/post-abortion, and those undergoing medical abortion, with lower continuation rates observed in general reproductive-age women due to abnormal menstruation.