Summary

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• Nexobrid (anacaulase) is indicated for eschar removal in adults with deep partial thickness and/or full thickness thermal burns.
• This summary is based on the review of two systematic review(s)/meta-analysis(es). ^[1-2]
• NexoBrid® demonstrates effectiveness in burn debridement and healing, leading to faster debridement times, reduced need for surgical operations, shorter hospital stays, decreased incidence of sepsis and blood transfusions, and prevention of compartment syndrome in patients with burns.
• Compared to other enzymatic debriding agents, such as collagenase and papain, NexoBrid® is particularly effective for deep burns, significantly reducing the need for grafts, with no substantial adverse effects reported.
• NexoBrid® is characterized as a safe, selective, non-surgical eschar removal treatment with no strong evidence of significant adverse events such as coagulopathy or burn wound infections.
• There is no population types or subgroups information available in the reviewed studies.