Sitagliptin and metformin hydrochloride



Drug updated on 5/17/2024

Dosage FormTablet (oral; sitagliptin/metformin hydrochloride 50 mg/500 mg); Tablet (oral; sitagliptin/metformin hydrochloride 50 mg/1000 mg)
Drug ClassDipeptidyl peptidase-4 inhibitors and metformin hydrochloride
Ongoing and
Completed Studies


  • Indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

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  • Sitagliptin and metformin hydrochloride (Janumet) is indicated as an adjunct to diet and exercise for improving glycemic control in adults with type 2 diabetes mellitus. It has a robust safety profile, particularly regarding treatment adherence due to fewer total adverse events leading to premature discontinuation compared to Semaglutide.
  • Three studies were reviewed, focusing on different drugs and combinations for treating type 2 diabetes mellitus, including Janumet.
  • In terms of effectiveness, Janumet shows efficacy in controlling blood glucose levels, but may not be as effective as Semaglutide when considering parameters like HbA1c reduction, blood pressure management, and weight loss.
  • For the pediatric population with Type 2 Diabetes Mellitus, a combination of sitagliptin and metformin therapies showed efficacy in reducing HbA1c without significant differences in adverse events, except for specific combinations noted.
  • Gemigliptin demonstrated a comparable safety profile against an active control group that included sitagliptin, with its ability to achieve and maintain glycemic control without increasing the risk of hypoglycemia or other adverse events highlighted.
  • The choice between using Janumet versus alternatives such as Semaglutide might depend on patient-specific goals, such as the degree of desired HbA1c reduction or weight management, along with tolerance towards potential side effects.